Combined poly(isobutylcyanoacrylate) and cyclodextrins nanoparticles for enhancing the encapsulation of lipophilic drugs

The aim of this study was to prepare and characterize nanoparticulate systems constituted of poly(isobutylcyanoacrylate) and cyclodextrins and intended for increasing the loading of the particles with lipophilic substances. Progesterone was used as a model substance. Nanoparticles were prepared by p...

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Bibliographic Details
Published in:Pharmaceutical research 1998-07, Vol.15 (7), p.1051-1055
Main Authors: MONZA DA SILVEIRA, A, PONCHEL, G, PUISIEUX, F, DUCHENE, D
Format: Article
Language:English
Subjects:
2-Hydroxypropyl-beta-cyclodextrin
beta-Cyclodextrins
Biological and medical sciences
Bucrylate - chemistry
Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid
Cyclodextrins - chemistry
Drug Carriers
Drug delivery systems
Drugs
General pharmacology
Genital system. Reproduction
Hydrochloric acid
Medical sciences
Nanoparticles
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymerization
Progesterone - administration & dosage
Surface-Active Agents - chemistry
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Summary:The aim of this study was to prepare and characterize nanoparticulate systems constituted of poly(isobutylcyanoacrylate) and cyclodextrins and intended for increasing the loading of the particles with lipophilic substances. Progesterone was used as a model substance. Nanoparticles were prepared by polymerization of isobutylcyanoacrylate in presence of cyclodextrins or progesterone/ hydroxypropyl-beta-cyclodextrin complex. Particle size, zeta potential, cyclodextrin and progesterone loading of the particles were determined. Nanoparticles could be easily prepared in presence of cyclodextrins. An increase in hydroxypropyl-beta-cyclodextrin concentration resulted in small nanoparticles (less than 50 nm). It was found that large amounts of cyclodextrins remained associated to the particles, resulting in a 50 fold increase in progesterone loading compared to nanoparticles prepared in absence of cyclodextrins. The poly(isobutylcyanoacrylate)cyclodextrin nanoparticles were characterized by the presence of many lipophilic sites belonging to the cyclodextrins which were firmly anchored to the structure of the particles. Therefore, this new type of nanoparticles offers probably an opportunity for increasing the loading of nanoparticles with various lipophilic drugs.
ISSN:0724-8741
1573-904X
DOI:10.1023/A:1011982211632