Loading…
Combined poly(isobutylcyanoacrylate) and cyclodextrins nanoparticles for enhancing the encapsulation of lipophilic drugs
The aim of this study was to prepare and characterize nanoparticulate systems constituted of poly(isobutylcyanoacrylate) and cyclodextrins and intended for increasing the loading of the particles with lipophilic substances. Progesterone was used as a model substance. Nanoparticles were prepared by p...
Saved in:
| Published in: | Pharmaceutical research 1998-07, Vol.15 (7), p.1051-1055 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c308t-a42e6074d0178fac2e20d9106964dd7e9ec4b512e1ac20f8273f68b4f61e2c353 |
|---|---|
| cites | |
| container_end_page | 1055 |
| container_issue | 7 |
| container_start_page | 1051 |
| container_title | Pharmaceutical research |
| container_volume | 15 |
| creator | MONZA DA SILVEIRA, A PONCHEL, G PUISIEUX, F DUCHENE, D |
| description | The aim of this study was to prepare and characterize nanoparticulate systems constituted of poly(isobutylcyanoacrylate) and cyclodextrins and intended for increasing the loading of the particles with lipophilic substances. Progesterone was used as a model substance.
Nanoparticles were prepared by polymerization of isobutylcyanoacrylate in presence of cyclodextrins or progesterone/ hydroxypropyl-beta-cyclodextrin complex. Particle size, zeta potential, cyclodextrin and progesterone loading of the particles were determined.
Nanoparticles could be easily prepared in presence of cyclodextrins. An increase in hydroxypropyl-beta-cyclodextrin concentration resulted in small nanoparticles (less than 50 nm). It was found that large amounts of cyclodextrins remained associated to the particles, resulting in a 50 fold increase in progesterone loading compared to nanoparticles prepared in absence of cyclodextrins.
The poly(isobutylcyanoacrylate)cyclodextrin nanoparticles were characterized by the presence of many lipophilic sites belonging to the cyclodextrins which were firmly anchored to the structure of the particles. Therefore, this new type of nanoparticles offers probably an opportunity for increasing the loading of nanoparticles with various lipophilic drugs. |
| doi_str_mv | 10.1023/A:1011982211632 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_80042666</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>520261691</sourcerecordid><originalsourceid>FETCH-LOGICAL-c308t-a42e6074d0178fac2e20d9106964dd7e9ec4b512e1ac20f8273f68b4f61e2c353</originalsourceid><addsrcrecordid>eNpdkE1r3DAQhkVJSTfbnnsKiBJCe3A7GmklObew9AsCvbTQm5ElOauglVzJhvjf1yVLDzkNw_O8w_AS8pbBRwbIP93eMGCs1YiMSY4vyIbtFG9aEL_PyAYUikYrwV6Ri1ofAECzVpyT81ZqDbt2Qx73-diH5B0dc1zeh5r7eVqiXUzKxpYlmsl_oCY5ahcbs_OPUwmp0rTy0ZQp2OgrHXKhPh1MsiHd0-ng182asc5rPORE80BjGPN4CDFY6sp8X1-Tl4OJ1b85zS359eXzz_235u7H1-_727vGctBTYwR6CUo4YEoPxqJHcC0D2UrhnPKtt6LfMfRsZTBoVHyQuheDZB4t3_EtuX66O5b8Z_Z16o6hWh-jST7PtdMAAqWUq_jumfiQ55LW3zpEVMA4ilW6PElzf_SuG0s4mrJ0pz5XfnXiploTh_KvkvpfQ644Ssb_Aq5Ghjg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222701324</pqid></control><display><type>article</type><title>Combined poly(isobutylcyanoacrylate) and cyclodextrins nanoparticles for enhancing the encapsulation of lipophilic drugs</title><source>Springer Nature</source><creator>MONZA DA SILVEIRA, A ; PONCHEL, G ; PUISIEUX, F ; DUCHENE, D</creator><creatorcontrib>MONZA DA SILVEIRA, A ; PONCHEL, G ; PUISIEUX, F ; DUCHENE, D</creatorcontrib><description>The aim of this study was to prepare and characterize nanoparticulate systems constituted of poly(isobutylcyanoacrylate) and cyclodextrins and intended for increasing the loading of the particles with lipophilic substances. Progesterone was used as a model substance.
Nanoparticles were prepared by polymerization of isobutylcyanoacrylate in presence of cyclodextrins or progesterone/ hydroxypropyl-beta-cyclodextrin complex. Particle size, zeta potential, cyclodextrin and progesterone loading of the particles were determined.
Nanoparticles could be easily prepared in presence of cyclodextrins. An increase in hydroxypropyl-beta-cyclodextrin concentration resulted in small nanoparticles (less than 50 nm). It was found that large amounts of cyclodextrins remained associated to the particles, resulting in a 50 fold increase in progesterone loading compared to nanoparticles prepared in absence of cyclodextrins.
The poly(isobutylcyanoacrylate)cyclodextrin nanoparticles were characterized by the presence of many lipophilic sites belonging to the cyclodextrins which were firmly anchored to the structure of the particles. Therefore, this new type of nanoparticles offers probably an opportunity for increasing the loading of nanoparticles with various lipophilic drugs.</description><identifier>ISSN: 0724-8741</identifier><identifier>EISSN: 1573-904X</identifier><identifier>DOI: 10.1023/A:1011982211632</identifier><identifier>PMID: 9688059</identifier><identifier>CODEN: PHREEB</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>2-Hydroxypropyl-beta-cyclodextrin ; beta-Cyclodextrins ; Biological and medical sciences ; Bucrylate - chemistry ; Chemistry, Pharmaceutical ; Chromatography, High Pressure Liquid ; Cyclodextrins - chemistry ; Drug Carriers ; Drug delivery systems ; Drugs ; General pharmacology ; Genital system. Reproduction ; Hydrochloric acid ; Medical sciences ; Nanoparticles ; Particle Size ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Polymerization ; Progesterone - administration & dosage ; Surface-Active Agents - chemistry</subject><ispartof>Pharmaceutical research, 1998-07, Vol.15 (7), p.1051-1055</ispartof><rights>1998 INIST-CNRS</rights><rights>Copyright Kluwer Academic Publishers Jul 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c308t-a42e6074d0178fac2e20d9106964dd7e9ec4b512e1ac20f8273f68b4f61e2c353</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2373261$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9688059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MONZA DA SILVEIRA, A</creatorcontrib><creatorcontrib>PONCHEL, G</creatorcontrib><creatorcontrib>PUISIEUX, F</creatorcontrib><creatorcontrib>DUCHENE, D</creatorcontrib><title>Combined poly(isobutylcyanoacrylate) and cyclodextrins nanoparticles for enhancing the encapsulation of lipophilic drugs</title><title>Pharmaceutical research</title><addtitle>Pharm Res</addtitle><description>The aim of this study was to prepare and characterize nanoparticulate systems constituted of poly(isobutylcyanoacrylate) and cyclodextrins and intended for increasing the loading of the particles with lipophilic substances. Progesterone was used as a model substance.
Nanoparticles were prepared by polymerization of isobutylcyanoacrylate in presence of cyclodextrins or progesterone/ hydroxypropyl-beta-cyclodextrin complex. Particle size, zeta potential, cyclodextrin and progesterone loading of the particles were determined.
Nanoparticles could be easily prepared in presence of cyclodextrins. An increase in hydroxypropyl-beta-cyclodextrin concentration resulted in small nanoparticles (less than 50 nm). It was found that large amounts of cyclodextrins remained associated to the particles, resulting in a 50 fold increase in progesterone loading compared to nanoparticles prepared in absence of cyclodextrins.
The poly(isobutylcyanoacrylate)cyclodextrin nanoparticles were characterized by the presence of many lipophilic sites belonging to the cyclodextrins which were firmly anchored to the structure of the particles. Therefore, this new type of nanoparticles offers probably an opportunity for increasing the loading of nanoparticles with various lipophilic drugs.</description><subject>2-Hydroxypropyl-beta-cyclodextrin</subject><subject>beta-Cyclodextrins</subject><subject>Biological and medical sciences</subject><subject>Bucrylate - chemistry</subject><subject>Chemistry, Pharmaceutical</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cyclodextrins - chemistry</subject><subject>Drug Carriers</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>General pharmacology</subject><subject>Genital system. Reproduction</subject><subject>Hydrochloric acid</subject><subject>Medical sciences</subject><subject>Nanoparticles</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymerization</subject><subject>Progesterone - administration & dosage</subject><subject>Surface-Active Agents - chemistry</subject><issn>0724-8741</issn><issn>1573-904X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNpdkE1r3DAQhkVJSTfbnnsKiBJCe3A7GmklObew9AsCvbTQm5ElOauglVzJhvjf1yVLDzkNw_O8w_AS8pbBRwbIP93eMGCs1YiMSY4vyIbtFG9aEL_PyAYUikYrwV6Ri1ofAECzVpyT81ZqDbt2Qx73-diH5B0dc1zeh5r7eVqiXUzKxpYlmsl_oCY5ahcbs_OPUwmp0rTy0ZQp2OgrHXKhPh1MsiHd0-ng182asc5rPORE80BjGPN4CDFY6sp8X1-Tl4OJ1b85zS359eXzz_235u7H1-_727vGctBTYwR6CUo4YEoPxqJHcC0D2UrhnPKtt6LfMfRsZTBoVHyQuheDZB4t3_EtuX66O5b8Z_Z16o6hWh-jST7PtdMAAqWUq_jumfiQ55LW3zpEVMA4ilW6PElzf_SuG0s4mrJ0pz5XfnXiploTh_KvkvpfQ644Ssb_Aq5Ghjg</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>MONZA DA SILVEIRA, A</creator><creator>PONCHEL, G</creator><creator>PUISIEUX, F</creator><creator>DUCHENE, D</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>19980701</creationdate><title>Combined poly(isobutylcyanoacrylate) and cyclodextrins nanoparticles for enhancing the encapsulation of lipophilic drugs</title><author>MONZA DA SILVEIRA, A ; PONCHEL, G ; PUISIEUX, F ; DUCHENE, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c308t-a42e6074d0178fac2e20d9106964dd7e9ec4b512e1ac20f8273f68b4f61e2c353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>2-Hydroxypropyl-beta-cyclodextrin</topic><topic>beta-Cyclodextrins</topic><topic>Biological and medical sciences</topic><topic>Bucrylate - chemistry</topic><topic>Chemistry, Pharmaceutical</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cyclodextrins - chemistry</topic><topic>Drug Carriers</topic><topic>Drug delivery systems</topic><topic>Drugs</topic><topic>General pharmacology</topic><topic>Genital system. Reproduction</topic><topic>Hydrochloric acid</topic><topic>Medical sciences</topic><topic>Nanoparticles</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymerization</topic><topic>Progesterone - administration & dosage</topic><topic>Surface-Active Agents - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MONZA DA SILVEIRA, A</creatorcontrib><creatorcontrib>PONCHEL, G</creatorcontrib><creatorcontrib>PUISIEUX, F</creatorcontrib><creatorcontrib>DUCHENE, D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmaceutical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MONZA DA SILVEIRA, A</au><au>PONCHEL, G</au><au>PUISIEUX, F</au><au>DUCHENE, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined poly(isobutylcyanoacrylate) and cyclodextrins nanoparticles for enhancing the encapsulation of lipophilic drugs</atitle><jtitle>Pharmaceutical research</jtitle><addtitle>Pharm Res</addtitle><date>1998-07-01</date><risdate>1998</risdate><volume>15</volume><issue>7</issue><spage>1051</spage><epage>1055</epage><pages>1051-1055</pages><issn>0724-8741</issn><eissn>1573-904X</eissn><coden>PHREEB</coden><abstract>The aim of this study was to prepare and characterize nanoparticulate systems constituted of poly(isobutylcyanoacrylate) and cyclodextrins and intended for increasing the loading of the particles with lipophilic substances. Progesterone was used as a model substance.
Nanoparticles were prepared by polymerization of isobutylcyanoacrylate in presence of cyclodextrins or progesterone/ hydroxypropyl-beta-cyclodextrin complex. Particle size, zeta potential, cyclodextrin and progesterone loading of the particles were determined.
Nanoparticles could be easily prepared in presence of cyclodextrins. An increase in hydroxypropyl-beta-cyclodextrin concentration resulted in small nanoparticles (less than 50 nm). It was found that large amounts of cyclodextrins remained associated to the particles, resulting in a 50 fold increase in progesterone loading compared to nanoparticles prepared in absence of cyclodextrins.
The poly(isobutylcyanoacrylate)cyclodextrin nanoparticles were characterized by the presence of many lipophilic sites belonging to the cyclodextrins which were firmly anchored to the structure of the particles. Therefore, this new type of nanoparticles offers probably an opportunity for increasing the loading of nanoparticles with various lipophilic drugs.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>9688059</pmid><doi>10.1023/A:1011982211632</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0724-8741 |
| ispartof | Pharmaceutical research, 1998-07, Vol.15 (7), p.1051-1055 |
| issn | 0724-8741 1573-904X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80042666 |
| source | Springer Nature |
| subjects | 2-Hydroxypropyl-beta-cyclodextrin beta-Cyclodextrins Biological and medical sciences Bucrylate - chemistry Chemistry, Pharmaceutical Chromatography, High Pressure Liquid Cyclodextrins - chemistry Drug Carriers Drug delivery systems Drugs General pharmacology Genital system. Reproduction Hydrochloric acid Medical sciences Nanoparticles Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymerization Progesterone - administration & dosage Surface-Active Agents - chemistry |
| title | Combined poly(isobutylcyanoacrylate) and cyclodextrins nanoparticles for enhancing the encapsulation of lipophilic drugs |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T16%3A07%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Combined%20poly(isobutylcyanoacrylate)%20and%20cyclodextrins%20nanoparticles%20for%20enhancing%20the%20encapsulation%20of%20lipophilic%20drugs&rft.jtitle=Pharmaceutical%20research&rft.au=MONZA%20DA%20SILVEIRA,%20A&rft.date=1998-07-01&rft.volume=15&rft.issue=7&rft.spage=1051&rft.epage=1055&rft.pages=1051-1055&rft.issn=0724-8741&rft.eissn=1573-904X&rft.coden=PHREEB&rft_id=info:doi/10.1023/A:1011982211632&rft_dat=%3Cproquest_pubme%3E520261691%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c308t-a42e6074d0178fac2e20d9106964dd7e9ec4b512e1ac20f8273f68b4f61e2c353%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=222701324&rft_id=info:pmid/9688059&rfr_iscdi=true |