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Trisomy 6 Is the Hallmark of a Dysplastic Clone in Bone Marrow Aplasia
Clonal hematopoiesis with trisomy 6 as the sole karyotypic change was revealed by cytogenetics in two cases of aplastic anemia. In both patients, dyserythropoiesis was characterized by asynchrony of maturation between nucleus and cytoplasm, binucleated elements, and intercytoplasmic connections. In...
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| Published in: | Cancer genetics and cytogenetics 1998-08, Vol.105 (1), p.55-59 |
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| container_end_page | 59 |
| container_issue | 1 |
| container_start_page | 55 |
| container_title | Cancer genetics and cytogenetics |
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| creator | La Starza, Roberta Matteucci, Caterina Crescenzi, Barbara Criel, Arnold Selleslag, Dominik Martelli, Massimo F Van den Berghe, Herman Mecucci, Cristina |
| description | Clonal hematopoiesis with trisomy 6 as the sole karyotypic change was revealed by cytogenetics in two cases of aplastic anemia. In both patients, dyserythropoiesis was characterized by asynchrony of maturation between nucleus and cytoplasm, binucleated elements, and intercytoplasmic connections. In addition to conventional cytogenetics, the size of the trisomic clone was evaluated by fluorescence in situ hybridization on fixed cells at diagnosis and in the course of the disease by using an
α-satellite centromeric probe for chromosome 6. Moreover, in situ hybridization on bone marrow smears showed that dysplastic erythrocytes as well as myeloid cells belonged to the trisomic clone. Trisomy 6 identifies a subgroup of hematologic disorders with bone marrow hypo-aplasia and dyserythropoiesis. |
| doi_str_mv | 10.1016/S0165-4608(97)00476-7 |
| format | article |
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α-satellite centromeric probe for chromosome 6. Moreover, in situ hybridization on bone marrow smears showed that dysplastic erythrocytes as well as myeloid cells belonged to the trisomic clone. Trisomy 6 identifies a subgroup of hematologic disorders with bone marrow hypo-aplasia and dyserythropoiesis.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/S0165-4608(97)00476-7</identifier><identifier>PMID: 9689931</identifier><identifier>CODEN: CGCYDF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Anemia, Aplastic - genetics ; Anemia, Aplastic - pathology ; Biological and medical sciences ; Bone Marrow Cells - pathology ; Chromosomes, Human, Pair 6 - genetics ; Clone Cells - pathology ; Female ; Hematologic and hematopoietic diseases ; Humans ; In Situ Hybridization, Fluorescence ; Karyotyping ; Medical sciences ; Middle Aged ; Other diseases. Hematologic involvement in other diseases ; Trisomy - genetics ; Trisomy - pathology</subject><ispartof>Cancer genetics and cytogenetics, 1998-08, Vol.105 (1), p.55-59</ispartof><rights>1998 Elsevier Science Inc.</rights><rights>1998 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-1ab2c503a60ea2a5fdc79d62824bb03598ea5b3af6144ef2f434f20c0e9255fc3</citedby><cites>FETCH-LOGICAL-c389t-1ab2c503a60ea2a5fdc79d62824bb03598ea5b3af6144ef2f434f20c0e9255fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2338523$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9689931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>La Starza, Roberta</creatorcontrib><creatorcontrib>Matteucci, Caterina</creatorcontrib><creatorcontrib>Crescenzi, Barbara</creatorcontrib><creatorcontrib>Criel, Arnold</creatorcontrib><creatorcontrib>Selleslag, Dominik</creatorcontrib><creatorcontrib>Martelli, Massimo F</creatorcontrib><creatorcontrib>Van den Berghe, Herman</creatorcontrib><creatorcontrib>Mecucci, Cristina</creatorcontrib><title>Trisomy 6 Is the Hallmark of a Dysplastic Clone in Bone Marrow Aplasia</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>Clonal hematopoiesis with trisomy 6 as the sole karyotypic change was revealed by cytogenetics in two cases of aplastic anemia. In both patients, dyserythropoiesis was characterized by asynchrony of maturation between nucleus and cytoplasm, binucleated elements, and intercytoplasmic connections. In addition to conventional cytogenetics, the size of the trisomic clone was evaluated by fluorescence in situ hybridization on fixed cells at diagnosis and in the course of the disease by using an
α-satellite centromeric probe for chromosome 6. Moreover, in situ hybridization on bone marrow smears showed that dysplastic erythrocytes as well as myeloid cells belonged to the trisomic clone. Trisomy 6 identifies a subgroup of hematologic disorders with bone marrow hypo-aplasia and dyserythropoiesis.</description><subject>Anemia, Aplastic - genetics</subject><subject>Anemia, Aplastic - pathology</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Cells - pathology</subject><subject>Chromosomes, Human, Pair 6 - genetics</subject><subject>Clone Cells - pathology</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Karyotyping</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. 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Hematologic involvement in other diseases</topic><topic>Trisomy - genetics</topic><topic>Trisomy - pathology</topic><toplevel>online_resources</toplevel><creatorcontrib>La Starza, Roberta</creatorcontrib><creatorcontrib>Matteucci, Caterina</creatorcontrib><creatorcontrib>Crescenzi, Barbara</creatorcontrib><creatorcontrib>Criel, Arnold</creatorcontrib><creatorcontrib>Selleslag, Dominik</creatorcontrib><creatorcontrib>Martelli, Massimo F</creatorcontrib><creatorcontrib>Van den Berghe, Herman</creatorcontrib><creatorcontrib>Mecucci, Cristina</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>La Starza, Roberta</au><au>Matteucci, Caterina</au><au>Crescenzi, Barbara</au><au>Criel, Arnold</au><au>Selleslag, Dominik</au><au>Martelli, Massimo F</au><au>Van den Berghe, Herman</au><au>Mecucci, Cristina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trisomy 6 Is the Hallmark of a Dysplastic Clone in Bone Marrow Aplasia</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>1998-08-01</date><risdate>1998</risdate><volume>105</volume><issue>1</issue><spage>55</spage><epage>59</epage><pages>55-59</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><coden>CGCYDF</coden><abstract>Clonal hematopoiesis with trisomy 6 as the sole karyotypic change was revealed by cytogenetics in two cases of aplastic anemia. In both patients, dyserythropoiesis was characterized by asynchrony of maturation between nucleus and cytoplasm, binucleated elements, and intercytoplasmic connections. In addition to conventional cytogenetics, the size of the trisomic clone was evaluated by fluorescence in situ hybridization on fixed cells at diagnosis and in the course of the disease by using an
α-satellite centromeric probe for chromosome 6. Moreover, in situ hybridization on bone marrow smears showed that dysplastic erythrocytes as well as myeloid cells belonged to the trisomic clone. Trisomy 6 identifies a subgroup of hematologic disorders with bone marrow hypo-aplasia and dyserythropoiesis.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9689931</pmid><doi>10.1016/S0165-4608(97)00476-7</doi><tpages>5</tpages></addata></record> |
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| language | eng |
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| source | Elsevier |
| subjects | Anemia, Aplastic - genetics Anemia, Aplastic - pathology Biological and medical sciences Bone Marrow Cells - pathology Chromosomes, Human, Pair 6 - genetics Clone Cells - pathology Female Hematologic and hematopoietic diseases Humans In Situ Hybridization, Fluorescence Karyotyping Medical sciences Middle Aged Other diseases. Hematologic involvement in other diseases Trisomy - genetics Trisomy - pathology |
| title | Trisomy 6 Is the Hallmark of a Dysplastic Clone in Bone Marrow Aplasia |
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