Constitutional Balanced Translocations in Alveolar Rhabdomyosarcoma

Chromosomal analysis of tumor tissue from two children with alveolar rhabdomyosarcoma revealed t(1;5)(q32;q31) and t(1;22)(q21;q11.2) in all metaphases examined, respectively. Peripheral blood lymphocytes carried the same cytogenetic abnormality as that of the tumor cells in both patients. Parental...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 1998-08, Vol.105 (1), p.50-54
Main Authors: Savaşan, Süreyya, Lorenzana, Adonis, Williams, James A., Mohamed, Anwar N., Ravindranath, Yaddanapudi, Zielenska, Maria, Hamre, Merlin, Haas, Joel E., Rector, Fredrick, Sawaf, Hadi, Abella, Esteban
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child
Child, Preschool
Chromosomes, Human, Pair 1 - genetics
Chromosomes, Human, Pair 22 - genetics
Chromosomes, Human, Pair 5 - genetics
Diseases of the osteoarticular system
Fatal Outcome
Humans
Karyotyping
Leg
Male
Medical sciences
Muscle Neoplasms - genetics
Rhabdomyosarcoma, Alveolar - genetics
Spinal Neoplasms - genetics
Translocation, Genetic - genetics
Tumors of striated muscle and skeleton
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Summary:Chromosomal analysis of tumor tissue from two children with alveolar rhabdomyosarcoma revealed t(1;5)(q32;q31) and t(1;22)(q21;q11.2) in all metaphases examined, respectively. Peripheral blood lymphocytes carried the same cytogenetic abnormality as that of the tumor cells in both patients. Parental lymphocytes were karyotypically normal in the patient with t(1;22), indicating a de novo constitutional translocation, but t(1;5) was paternally inherited in the other patient. The presence of constitutional translocations in these two children might have contributed to the development of alveolar rhabdomyosarcoma.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(98)00014-4