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Constitutional Balanced Translocations in Alveolar Rhabdomyosarcoma

Chromosomal analysis of tumor tissue from two children with alveolar rhabdomyosarcoma revealed t(1;5)(q32;q31) and t(1;22)(q21;q11.2) in all metaphases examined, respectively. Peripheral blood lymphocytes carried the same cytogenetic abnormality as that of the tumor cells in both patients. Parental...

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Published in:	Cancer genetics and cytogenetics 1998-08, Vol.105 (1), p.50-54
Main Authors:	Savaşan, Süreyya, Lorenzana, Adonis, Williams, James A., Mohamed, Anwar N., Ravindranath, Yaddanapudi, Zielenska, Maria, Hamre, Merlin, Haas, Joel E., Rector, Fredrick, Sawaf, Hadi, Abella, Esteban
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Language:	English
Subjects:	Biological and medical sciences Child Child, Preschool Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 22 - genetics Chromosomes, Human, Pair 5 - genetics Diseases of the osteoarticular system Fatal Outcome Humans Karyotyping Leg Male Medical sciences Muscle Neoplasms - genetics Rhabdomyosarcoma, Alveolar - genetics Spinal Neoplasms - genetics Translocation, Genetic - genetics Tumors of striated muscle and skeleton
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creator	Savaşan, Süreyya Lorenzana, Adonis Williams, James A. Mohamed, Anwar N. Ravindranath, Yaddanapudi Zielenska, Maria Hamre, Merlin Haas, Joel E. Rector, Fredrick Sawaf, Hadi Abella, Esteban
description	Chromosomal analysis of tumor tissue from two children with alveolar rhabdomyosarcoma revealed t(1;5)(q32;q31) and t(1;22)(q21;q11.2) in all metaphases examined, respectively. Peripheral blood lymphocytes carried the same cytogenetic abnormality as that of the tumor cells in both patients. Parental lymphocytes were karyotypically normal in the patient with t(1;22), indicating a de novo constitutional translocation, but t(1;5) was paternally inherited in the other patient. The presence of constitutional translocations in these two children might have contributed to the development of alveolar rhabdomyosarcoma.
doi_str_mv	10.1016/S0165-4608(98)00014-4
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The presence of constitutional translocations in these two children might have contributed to the development of alveolar rhabdomyosarcoma.</description><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromosomes, Human, Pair 1 - genetics</subject><subject>Chromosomes, Human, Pair 22 - genetics</subject><subject>Chromosomes, Human, Pair 5 - genetics</subject><subject>Diseases of the osteoarticular system</subject><subject>Fatal Outcome</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Leg</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle Neoplasms - genetics</subject><subject>Rhabdomyosarcoma, Alveolar - genetics</subject><subject>Spinal Neoplasms - genetics</subject><subject>Translocation, Genetic - genetics</subject><subject>Tumors of striated muscle and skeleton</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFkMtKxDAUhoMoOo4-gtCFiC6quTVNVzIO3mBA8LIOp7lgpG006Qi-vRlnmK2bcxb_dy58CJ0QfEkwEVcvuVQlF1ieN_ICY0x4yXfQhMialZxXYhdNtsgBOkzpI0M1bcQ-2m-EbBqGJ2g-D0Ma_bgcfRigK26gg0FbU7xGGFIXNKyCVPihmHXfNnQQi-d3aE3of0KCqEMPR2jPQZfs8aZP0dvd7ev8oVw83T_OZ4tSM9mMpbCGtcIYxym0nDoHXHCHLTc1OCcFtLaWQKVtaEUMVBUTJKeM1JRzXbdsis7Wez9j-FraNKreJ227_LENy6QkxpzRqs5gtQZ1DClF69Rn9D3EH0WwWslTf_LUyoxqpPqTp3ieO9kcWLa9Ndupja2cn25ySBo6lxVpn7YYZUxWlGTseo3ZLOPb26iS9nZl1UerR2WC_-eRX0SOjBI</recordid><startdate>19980801</startdate><enddate>19980801</enddate><creator>Savaşan, Süreyya</creator><creator>Lorenzana, Adonis</creator><creator>Williams, James A.</creator><creator>Mohamed, Anwar N.</creator><creator>Ravindranath, Yaddanapudi</creator><creator>Zielenska, Maria</creator><creator>Hamre, Merlin</creator><creator>Haas, Joel E.</creator><creator>Rector, Fredrick</creator><creator>Sawaf, Hadi</creator><creator>Abella, Esteban</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980801</creationdate><title>Constitutional Balanced Translocations in Alveolar Rhabdomyosarcoma</title><author>Savaşan, Süreyya ; 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subjects	Biological and medical sciences Child Child, Preschool Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 22 - genetics Chromosomes, Human, Pair 5 - genetics Diseases of the osteoarticular system Fatal Outcome Humans Karyotyping Leg Male Medical sciences Muscle Neoplasms - genetics Rhabdomyosarcoma, Alveolar - genetics Spinal Neoplasms - genetics Translocation, Genetic - genetics Tumors of striated muscle and skeleton
title	Constitutional Balanced Translocations in Alveolar Rhabdomyosarcoma
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