Effect of aminoguanidine on optic nerve involvement in experimental diabetic rats

The effect of aminoguanidine (AG) on structural abnormalities in optic nerve fibers was evaluated in streptozotocin-induced diabetic rats. Morphometry of myelinated optic nerve fibers showed a partial amelioration on the reduction of the axon size but complete preservation of myelin size with low do...

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Bibliographic Details
Published in:Brain research 1998-08, Vol.800 (2), p.319-322
Main Authors: Ino-ue, Masanori, Ohgiya, Nobuaki, Yamamoto, Misao
Format: Article
Language:English
Subjects:
Aminoguanidine
Animals
Biological and medical sciences
Body Weight
Diabetes Mellitus, Experimental - complications
Diabetes. Impaired glucose tolerance
Diabetic Neuropathies - drug therapy
Diabetic Neuropathies - enzymology
Dose-Response Relationship, Drug
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Enzyme Inhibitors - pharmacology
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Glycation End Products, Advanced - antagonists & inhibitors
Glycation End Products, Advanced - metabolism
Guanidines - pharmacology
Male
Medical sciences
Morphometry
Nerve Fibers, Myelinated - drug effects
Nerve Fibers, Myelinated - metabolism
Nonenzymatic glycation
Optic myelinated fiber
Optic Nerve Diseases - drug therapy
Optic Nerve Diseases - enzymology
Rats
Rats, Wistar
Streptozotocin-induced diabetes
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Summary:The effect of aminoguanidine (AG) on structural abnormalities in optic nerve fibers was evaluated in streptozotocin-induced diabetic rats. Morphometry of myelinated optic nerve fibers showed a partial amelioration on the reduction of the axon size but complete preservation of myelin size with low dose (25 mg kg −1 body weight) AG treatment. High dose (100 mg kg −1 body weight) AG completely prevented myelinated nerve fiber atrophy. These findings indicated that nonenzymatic glycation contributes to the development of optic nerve changes in diabetic rats.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(98)00512-5