Co-administration of cyclosporin enables oral therapy with paclitaxel

Terwogt et al determined whether co-administration of cyclosporin (Cs) might increase the absorption of oral paclitaxel. Co-administration of the P-gp inhibitor Cs increases absorption of oral paclitaxel to therapeutic plasma concentrations.

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Bibliographic Details
Published in:The Lancet (British edition) 1998-07, Vol.352 (9124), p.285-285
Main Authors: Terwogt, Jetske M Meerum, Beijnen, Jos H, Huinink, Wim W ten Bokkel, Rosing, Hilde, Schellens, Jan HM
Format: Article
Language:English
Subjects:
Absorption
Administration, Oral
Animals
Antineoplastic agents
Antineoplastic Agents, Phytogenic - administration & dosage
Antineoplastic Agents, Phytogenic - pharmacokinetics
ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors
Biological and medical sciences
Biological Availability
Chemotherapy
Cyclosporine - administration & dosage
Drug therapy
Drug Therapy, Combination
Humans
Infusions, Intravenous
Medical sciences
Mice
Mice, Knockout
Neoplasms - drug therapy
Paclitaxel - administration & dosage
Paclitaxel - pharmacokinetics
Pharmacology. Drug treatments
Side effects
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Description
Summary:Terwogt et al determined whether co-administration of cyclosporin (Cs) might increase the absorption of oral paclitaxel. Co-administration of the P-gp inhibitor Cs increases absorption of oral paclitaxel to therapeutic plasma concentrations.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(98)24030-X