Cellular cholesterol synthesis—The relationship to post-prandial glucose and insulin following weight loss

Hyperinsulinaemia is a risk factor for atherosclerosis. We have previously demonstrated a relationship between hyperinsulinaemia and cellular cholesterol synthesis. In this paper we examine the separate relationship of glucose and insulin to cholesterol synthesis in three groups of obese patients. T...

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Bibliographic Details
Published in:Atherosclerosis 1998-06, Vol.138 (2), p.313-318
Main Authors: Griffin, Margaret, Frazer, Alexander, Johnson, Alan, Collins, Patrick, Owens, Daphne, Tomkin, Gerald H
Format: Article
Language:English
Subjects:
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Glucose - metabolism
Cardiology. Vascular system
Cholesterol - biosynthesis
Cholesterol synthesis
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - physiopathology
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - physiopathology
Humans
Hyperinsulinaemia
Hyperinsulinism - blood
Hyperinsulinism - physiopathology
Hypoglycemic Agents - blood
Hypoglycemic Agents - pharmacology
Insulin - blood
Insulin - pharmacology
Insulin Resistance
Medical sciences
NIDDM
Postprandial Period
Weight Loss
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Summary:Hyperinsulinaemia is a risk factor for atherosclerosis. We have previously demonstrated a relationship between hyperinsulinaemia and cellular cholesterol synthesis. In this paper we examine the separate relationship of glucose and insulin to cholesterol synthesis in three groups of obese patients. The first group was a group of non-insulin-dependent diabetic patients with a low post-prandial insulin response ( n=8). The second group had non-insulin-dependent diabetes and a high insulin response ( n=9). The third group were non-diabetic patients with a high post-prandial insulin ( n=12). Six diabetic and seven non-diabetic patients who were hyperinsulinaemic on initial analysis, were re-examined following an 8% body weight reduction. Insulin resistance was defined as the ratio of area under curve for insulin/area under curve for glucose. Cellular cholesterol synthesis was measured in freshly isolated mononuclear leucocytes. Fasting cholesterol synthesis was similar in the three groups. In both diabetic and non-diabetic high insulin subjects cholesterol synthesis rose significantly after the meal ( p
ISSN:0021-9150
1879-1484
DOI:10.1016/S0021-9150(98)00036-7