Effects of glutathione depletors on post-ischemic reperfusion in rat brain

The present paper reports the effects of GSH depletion (diethylmaleate induced) on partial cerebral ischemia and reperfusion for 7 and 20 days. Our results confirm that there is a paradoxical protective effect of the GSH-depletor and suggest an improved neuronal trophism induced by diethylmaleate tr...

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Bibliographic Details
Published in:Neurochemical research 1998-07, Vol.23 (7), p.961-968
Main Authors: MARTINEZ, G, CARNAZZA, M. L, CAMPISI, A, SORRENTI, V, DI GIACOMO, C, PEREZ-POLO, J. R, VANELLA, A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain
Brain - drug effects
Brain - metabolism
Brain - pathology
Brain Ischemia - metabolism
Glutathione - metabolism
Lactic Acid - metabolism
Male
Maleates - pharmacology
Medical sciences
Neurology
Rats
Rats, Wistar
Reperfusion
Rodents
Vascular diseases and vascular malformations of the nervous system
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Summary:The present paper reports the effects of GSH depletion (diethylmaleate induced) on partial cerebral ischemia and reperfusion for 7 and 20 days. Our results confirm that there is a paradoxical protective effect of the GSH-depletor and suggest an improved neuronal trophism induced by diethylmaleate treatment.
ISSN:0364-3190
1573-6903
DOI:10.1023/A:1021080321320