Determination of Urine Saturation with Computer Program Equil 2 As a Method for Estimation of the Risk of Urolithiasis

To investigate the risk for the development of urolithiasis in 30 children with urolithiasis, 36 children with isolated hematuria, and 15 healthy control children, 24-h urinary excretion of calcium, sodium, oxalate, citrate, sulfate, phosphate, magnesium, urate, chloride, ammonium, and glycosaminogl...

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Published in:Journal of Chemical Information and Computer Sciences 1998-07, Vol.38 (4), p.646-650
Main Authors: Milošević, Danko, Batinić, Danica, Blau, Nenad, Konjevoda, Paško, Štambuk, Nikola, Votava-Raić, Ana, Barbarić, Vesna, Fumić, Ksenija, Rumenjak, Vlatko, Stavljenić-Rukavina, Ana, Nižić, Ljiljana, Vrljićak, Kristina
Format: Article
Language:English
Subjects:
Calcium - urine
Case-Control Studies
Child
Computerized information storage and retrieval
Crystallization
EQUIL 2
Hematuria - urine
Humans
Logistic Models
Oxalates - urine
Oxalic Acid
Risk Factors
Software
Solubilities
Urinary Calculi - chemistry
Urinary Calculi - etiology
Urine - chemistry
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Summary:To investigate the risk for the development of urolithiasis in 30 children with urolithiasis, 36 children with isolated hematuria, and 15 healthy control children, 24-h urinary excretion of calcium, sodium, oxalate, citrate, sulfate, phosphate, magnesium, urate, chloride, ammonium, and glycosaminoglycans was determined and urine saturation for calcium oxalate was calculated with the computer program EQUIL 2. Compared with controls, children with urolithiasis had significantly increased calcium excretion, oxalate excretion, and urine saturation, whereas children with isolated hematuria had significantly increased calcium excretion only. The best estimation of the relative risk of urolithiasis can be made after urine saturation, using logistic regression. The percentage of patients correctly classified after urine saturation is 85.41% in comparison with 80.95% and 73.81% when the estimation was done by calcium excretion and oxalate excretion, respectively. Using the breakpoint value of 4.29 for urine saturation, it was possible to separate children with increased risk of urolithiasis development from the group of children with isolated hematuria.
ISSN:0095-2338
1549-960X
1520-5142
DOI:10.1021/ci9701087