The Effect of the Sulfonylurea Glyburide on Nitric Oxide in Streptozotocin-Induced Diabetic Rat

1. The interaction between nitric oxide (NO) and superoxide anions has received a great deal of attention. Because NO is rapidly inactivated by superoxide anions, it has been suggested that an enhanced formation of this radical may be involved in the accelerated breakdown of NO. 2. In the present st...

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Bibliographic Details
Published in:General pharmacology 1998-08, Vol.31 (2), p.319-321
Main Authors: Altan, Nilgün, Buğdayci, Güler, Tutkun, Funda Kosova, Sancak, Banu, Nazaroğlu, Namik Kemal
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Diabetes
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - metabolism
glyburide
Glyburide - pharmacology
Hormones. Endocrine system
Hypoglycemic Agents - pharmacology
Male
Medical sciences
nitric oxide
Nitric Oxide - metabolism
nitrite plus nitrate
Pharmacology. Drug treatments
Rats
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Summary:1. The interaction between nitric oxide (NO) and superoxide anions has received a great deal of attention. Because NO is rapidly inactivated by superoxide anions, it has been suggested that an enhanced formation of this radical may be involved in the accelerated breakdown of NO. 2. In the present study, we administrated glyburide (glibenclamide) to Streptozotocin-induced diabetic rats and determined the effect of such treatment on serum nitrite+nitrate levels. Serum nitrite+nitrate levels were reduced in diabetic animals ( P
ISSN:0306-3623
1879-0011
DOI:10.1016/S0306-3623(97)00430-8