Evidence for strain specificity in cytotoxic T-lymphocyte-mediated, major histocompatibility complex class I-dependent killing of Theileria annulata-infected cells

Cattle immunised against Theileria annulata with one parasite strain have been found to be immune to re-challenge with different strains of the parasite. However, recent evidence of apparent strain specificity has been documented in cattle immunised with attenuated parasite-infected cells. In this s...

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Bibliographic Details
Published in:Parasitology research (1987) 1998-07, Vol.84 (7), p.593-595
Main Authors: CONZE, G, CAMPBELL, J. D. M, NICHANI, A. K, GLASS, E. J, SPOONER, R. L, AHMED, J. S
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cattle
Cell Line
Fundamental and applied biological sciences. Psychology
Histocompatibility Antigens Class I - immunology
Protozoa
Species Specificity
T-Lymphocytes, Cytotoxic - immunology
Theileria annulata - immunology
Theileriasis - immunology
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
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Summary:Cattle immunised against Theileria annulata with one parasite strain have been found to be immune to re-challenge with different strains of the parasite. However, recent evidence of apparent strain specificity has been documented in cattle immunised with attenuated parasite-infected cells. In this study the strain specificity of major histocompatibility complex class I-restricted cytotoxic T-lymphocytes (CTL), a major anti-parasite effector mechanism, was examined. CTL generated following challenge with the Hissar (Indian) strain effectively lysed autologous cells infected with this strain of the parasite. However, CTL were less effective against cells infected with the Gharb (Moroccan) strain and showed virtually no reactivity against the Ankara (Turkish) strain, providing the first direct evidence for strain specificity in immune responses against T. annulata.
ISSN:0932-0113
1432-1955
DOI:10.1007/s004360050455