Use of NMR imaging in the optimization of a compression-coated regulated release system

Nuclear magnetic resonance (NMR) imaging is routinely used to detect the protons of mobile water molecules within samples. In this investigation, this non-destructive, non-invasive technique was used to determine the cause for faster than predicted drug release from a dissolution-based regulated-rel...

Full description

Saved in:
Bibliographic Details
Published in:Journal of controlled release 1998-02, Vol.51 (2), p.179-184
Main Authors: Fahie, Brian J, Nangia, Avinash, Chopra, Sham K, Fyfe, Colin A, Grondey, Hiltrud, Blazek, Almira
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Cellulose - analogs & derivatives
Cellulose - chemistry
Compression coating
Delayed-Action Preparations - analysis
Formulation optimization
General pharmacology
Histamine H2 Antagonists - analysis
Lactose - chemistry
Magnetic Resonance Imaging - methods
Medical sciences
Methacrylates - chemistry
Modified-release tablet
NMR imaging
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Pressure
Ranitidine - analysis
Regulated-release tablet
Surface Properties
Tablets - analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nuclear magnetic resonance (NMR) imaging is routinely used to detect the protons of mobile water molecules within samples. In this investigation, this non-destructive, non-invasive technique was used to determine the cause for faster than predicted drug release from a dissolution-based regulated-release tablet. The NMR images of tablets, from two different formulations, taken at various intervals of time while immersed in static USP dissolution medium showed that the tablet with faster than predicted drug release had a porous coating. The porous coat exposed more of the core surface area to the dissolution medium than desired and this caused an increase in the rate of dissolution of the core. The data presented in this paper demonstrate the usefulness of NMR imaging in solid dosage form development.
ISSN:0168-3659
1873-4995
DOI:10.1016/S0168-3659(97)00166-1