Specificity of the solid phase alkaline phosphatase immunocapture assay for the diagnosis of human Schistosoma mansoni infection

The species specificity of the solid phase alkaline phosphatase immunocapture assay ( apia) for the immunological detection of human immunoglobulin G antibodies to the alkaline phosphatase of adult Schistosoma mansoni was evaluated. Sera from schistosomiasis patients from South America, West Africa,...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 1998, Vol.92 (1), p.38-39
Main Authors: Cesari, Italo M., Ferrer, Alain, Kombila, Maryvonne, Pichard, Eric, Decam, Christophe, Li-Shu, Qiu, Bout, Daniel, Richard-Lenoble, Dominique
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - analysis
Alkaline Phosphatase - immunology
alkaline phosphatase immunocapture assay
Antibodies, Helminth - analysis
Biological and medical sciences
Clinical Enzyme Tests - methods
Diseases caused by trematodes
Helminthic diseases
Humans
immunodiagnosis
Immunoglobulin G - analysis
Immunologic Tests - methods
Immunologic Tests - standards
Infectious diseases
Medical sciences
Parasitic diseases
Schistosoma mansoni
Schistosomiases
schistosomiasis
Schistosomiasis mansoni - diagnosis
Sensitivity and Specificity
Species Specificity
Tropical medicine
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Summary:The species specificity of the solid phase alkaline phosphatase immunocapture assay ( apia) for the immunological detection of human immunoglobulin G antibodies to the alkaline phosphatase of adult Schistosoma mansoni was evaluated. Sera from schistosomiasis patients from South America, West Africa, south-east Asia and uninfected control subjects were compared. Only the sera of patients infected with S. mansoni gave positive results. There was no apparent difference between 2 populations infected with S. mansoni, one from South America and the other from West Africa. The results with sera from various regions of West Africa were also indistinguishable. Although the apia was not able to discriminate the geographical origin of the S. mansoni-infected subjects, the method appeared to be specific for S. mansoni and suitable for use in the immunodiagnosis of schistosomiasis mansoni, particularly in endemic areas where mixed infections of Schistosoma spp. occur.
ISSN:0035-9203
1878-3503
DOI:10.1016/S0035-9203(98)90947-6