LDL oxidation: therapeutic perspectives

The peroxidation step of lipid transormation is considered to be essential in the pathogenesis of atherosclerosis. Although data concerning the mechanisms by which lipid peroxidation occurs in vivo are scarce, several lines of evidence suggest that some endogenous and exogenous compounds with antiox...

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Bibliographic Details
Published in:Atherosclerosis 1998-04, Vol.137, p.S25-S31
Main Authors: Heller, Francis R, Descamps, Olivier, Hondekijn, Jean-Claude
Format: Article
Language:English
Subjects:
Animals
Antioxidants - therapeutic use
Atherosclerosis
Biological and medical sciences
Coronary Artery Disease - prevention & control
Diet
Drugs
General and cellular metabolism. Vitamins
Humans
Lipoproteins, LDL - metabolism
Low density lipoproteins
Medical sciences
Oxidation
Oxidation-Reduction
Pharmacology. Drug treatments
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Summary:The peroxidation step of lipid transormation is considered to be essential in the pathogenesis of atherosclerosis. Although data concerning the mechanisms by which lipid peroxidation occurs in vivo are scarce, several lines of evidence suggest that some endogenous and exogenous compounds with antioxidant activity could have some beneficial effects in the prevention of atherosclerosis. Ascorbic acid (vitamin C) and α-tocopherol (vitamin E) act as the most important hydrophilic and lipophilic antoxidants, respectively in vivo. Accordingly, animal and human studies suggest that these compounds may have some preventive effect against the development of clinical coronary heart disease. Many plant phenols and flavonoids may be important dietary antioxidants and it has been speculated that these compounds in red wine or in the Mediterranean diet could explain the ‘French paradox’. Several studies show that antioxidants such as probucol and butylated hydroxytoluene can inhibit development of atherosclerotic lesions in Watanabe and cholesterol-fed rabbits. Some drugs such as β-blockers, calcium antagonists, hypolipodemic drugs,…appear to have at least in vitro antioxidant effects but the clinical relevance of these properties remains unkonwn. Moreover, some interventions aimed to decrease the LDL-oxidative susceptibility have not been shown to attenuate atherogenesis when cholesterol levels remain markedly elevated.
ISSN:0021-9150
1879-1484
DOI:10.1016/S0021-9150(97)00308-0