Speculating about spectrin: new insights into the Golgi-associated cytoskeleton

Amid the continual flux of membranes and proteins through the Golgi, the distinctive structure and compartmentalization of the cisternal stacks are preserved. Microtubules and associated motors are required to maintain Golgi structure and for transport to and from the organelle. There is also eviden...

Full description

Saved in:
Bibliographic Details
Published in:Trends in cell biology 1998, Vol.8 (1), p.26-29
Main Authors: Holleran, Elizabeth A., Holzbaur, Erika L.F.
Format: Article
Language:English
Subjects:
Animals
Cell Line
Cytoskeleton - metabolism
Cytoskeleton - physiology
Golgi Apparatus - metabolism
Golgi Apparatus - physiology
Humans
Spectrin - metabolism
Spectrin - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Amid the continual flux of membranes and proteins through the Golgi, the distinctive structure and compartmentalization of the cisternal stacks are preserved. Microtubules and associated motors are required to maintain Golgi structure and for transport to and from the organelle. There is also evidence for Golgi-associated myosins. Recent research has identified a novel Golgi-associated spectrin-based network. In this review, we discuss evidence for this network and the possible roles for spectrin in maintaining Golgi structure and in vesicular transport to and from the Golgi. Overall the link between the cytoskeleton and the Golgi appears to be dynamic in nature, in keeping with the continuous flux of proteins and lipids through this organelle.
ISSN:0962-8924
1879-3088
DOI:10.1016/S0962-8924(97)01195-1