The SAGA unfolds: convergence of transcription regulators in chromatin-modifying complexes

Several previously characterized transcriptional adaptors and coactivators are now known to be histone acetyltransferases (HATs). Recent studies in Saccharomyces cerevisiae indicate that the Gcn5p HAT exists in large complexes containing several phenotypic classes of transcription factors. Genetic a...

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Bibliographic Details
Published in:Trends in cell biology 1998-05, Vol.8 (5), p.193-197
Main Authors: Grant, Patrick A, Sterner, David E, Duggan, Laura J, Workman, Jerry L, Berger, Shelley L
Format: Article
Language:English
Subjects:
acetylation
Acetyltransferases - physiology
adaptor complex
Animals
Chromatin - metabolism
Chromatin - physiology
coactivator
gene expression
histone
Histone Acetyltransferases
Humans
Macromolecular Substances
Models, Biological
nucleosome
protein complex
Saccharomyces cerevisiae Proteins
SAGA
transcription
Transcription Factors - chemistry
Transcription Factors - physiology
yeast
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Summary:Several previously characterized transcriptional adaptors and coactivators are now known to be histone acetyltransferases (HATs). Recent studies in Saccharomyces cerevisiae indicate that the Gcn5p HAT exists in large complexes containing several phenotypic classes of transcription factors. Genetic and biochemical studies of these transcription factors and their functions within HAT complexes suggest that acetylation of histones is one function of an integrated system of modular activities. These activities include interaction with activators, histone acetylation and interaction with basal factors. Coordination of these functions may well be an important component of gene activation in vivo.
ISSN:0962-8924
1879-3088
DOI:10.1016/S0962-8924(98)01263-X