Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins : The atherosclerosis risk in communities (ARIC) study

Elevated plasma total homocysteine (tHcy), low B-vitamin intake, and genetic polymorphisms related to tHcy metabolism may play roles in coronary heart disease (CHD). More prospective studies are needed. We used a prospective case-cohort design to determine whether tHcy-related factors are associated...

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Published in:Circulation (New York, N.Y.) N.Y.), 1998-07, Vol.98 (3), p.204-210
Main Authors: FOLSOM, A. R, JAVIER, F. NIETO, MCGOVERN, P. G, TSAI, M. Y, MALINOW, M. R, ECKFELDT, J. H, HESS, D. L, DAVIS, C. E
Format: Article
Language:English
Subjects:
Arteriosclerosis - etiology
Biological and medical sciences
Cardiology. Vascular system
Cohort Studies
Coronary Disease - epidemiology
Coronary Disease - genetics
Coronary heart disease
Dietary Supplements
Fasting
Female
Folic Acid - administration & dosage
Folic Acid - blood
Heart
Homocysteine - blood
Humans
Incidence
Male
Medical sciences
Middle Aged
Polymorphism, Genetic - genetics
Prospective Studies
Pyridoxal Phosphate - blood
Risk Factors
Vitamin B 12 - administration & dosage
Vitamin B 12 - blood
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Summary:Elevated plasma total homocysteine (tHcy), low B-vitamin intake, and genetic polymorphisms related to tHcy metabolism may play roles in coronary heart disease (CHD). More prospective studies are needed. We used a prospective case-cohort design to determine whether tHcy-related factors are associated with incidence of CHD over an average of 3.3 years of follow-up in a biracial sample of middle-aged men and women. Age-, race-, and field center-adjusted CHD incidence was associated positively (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.98.3.204