THE EFFECT OF SUCCINIC ACID MONOMETHYL ESTER (SAM) ON THE RESPONSES OF ISOLATED THORACIC AORTA IN STREPTOZOTOCIN-DIABETIC RATS

Succinic acid monomethyl ester (SAM) was recently proposed as an insulinotropic tool in non-insulin-dependent diabetes mellitus. The present study was designed to define whether SAM has the vascular effect in thoracic aorta of streptozotocin (STZ)-diabetic rats. (1) Body weights of diabetic rats wer...

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Bibliographic Details
Published in:Pharmacological research 1998-07, Vol.38 (1), p.73-79
Main Authors: ÖZYAZGAN, S., SENSES, V., INCE, E., SULTUYBEK, G., UTKAN, T., AKKAN, A.G.
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Aorta, Thoracic - drug effects
Diabetes Mellitus, Experimental - drug therapy
Female
In Vitro Techniques
Male
Muscle, Smooth, Vascular - drug effects
Rats
Rats, Wistar
streptozotocin, succinic acid monomethyl ester, aorta, contraction
Succinates - pharmacology
Vasoconstrictor Agents - pharmacology
Vasodilator Agents - pharmacology
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Summary:Succinic acid monomethyl ester (SAM) was recently proposed as an insulinotropic tool in non-insulin-dependent diabetes mellitus. The present study was designed to define whether SAM has the vascular effect in thoracic aorta of streptozotocin (STZ)-diabetic rats. (1) Body weights of diabetic rats were significantly increased after SAM treatment (P
ISSN:1043-6618
1096-1186
DOI:10.1006/phrs.1998.0332