Loading…
Association of T‐786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease
Summary Acute chest syndrome (ACS) is a life‐threatening complication of sickle cell disease (SCD). A retrospective study was performed to evaluate the role of endothelial nitric oxide synthase (eNOS) gene polymorphisms (E298D and T‐786C) in African–American SCD patients. The D298 allele showed no a...
Saved in:
| Published in: | British journal of haematology 2004-01, Vol.124 (2), p.240-243 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4722-22c4001a8ecaee477c15b01476ee14967d9c7e3885dcad756d34b73c920093d43 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4722-22c4001a8ecaee477c15b01476ee14967d9c7e3885dcad756d34b73c920093d43 |
| container_end_page | 243 |
| container_issue | 2 |
| container_start_page | 240 |
| container_title | British journal of haematology |
| container_volume | 124 |
| creator | Sharan, K. Surrey, S. Ballas, S. Borowski, M. Devoto, M. Wang, K.‐F. Sandler, E. Keller, M. |
| description | Summary
Acute chest syndrome (ACS) is a life‐threatening complication of sickle cell disease (SCD). A retrospective study was performed to evaluate the role of endothelial nitric oxide synthase (eNOS) gene polymorphisms (E298D and T‐786C) in African–American SCD patients. The D298 allele showed no association; the C‐786 allele showed a statistically significant association (P = 0·0061) in female ACS cases. Multiple logistic regression analysis showed that relative risk of ACS was 8·695 (P = 0·0076, 95% confidence interval 1·761–42·920) for female carriers of C‐786. eNOS T‐786C is a gender‐specific genetic modifier that is associated with increased susceptibility to ACS in female SCD patients. |
| doi_str_mv | 10.1046/j.1365-2141.2003.04762.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80065436</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80065436</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4722-22c4001a8ecaee477c15b01476ee14967d9c7e3885dcad756d34b73c920093d43</originalsourceid><addsrcrecordid>eNqNkUFv1DAQhS0EotvCX0AWEtwS7NixkwOHsqIUVNED5Wx5nQnrJYkXT6I2N44c-Y38Ehx2RSVOnMbSfO_pjR8hlLOcM6le7XIuVJkVXPK8YEzkTGpV5HcPyOrv4iFZMcZ0lgTVCTlF3DHGBSv5Y3LCpao0E2pFfpwjBuft6MNAQ0tvfn3_qSu1pvDx-hP9AgPQfejmPsT91mNPb_24pX5wESxCQ3FCB_vRb3znx5mOgVo3jUDdFnCkOA9NDD0kAW2htx3gwQC9-9olCrqONh4XryfkUWs7hKfHeUY-X7y9WV9mV9fv3q_PrzIndVFkReFkusNW4CyA1NrxcsN4Oh-Ay1rppnYaRFWVjbONLlUj5EYLV6dvqkUjxRl5efDdx_BtSilN73EJYgcIE5qKMVVKoRL4_B9wF6Y4pGyG11WpFC9EgqoD5GJAjNCaffS9jbPhzCxVmZ1ZGjFLI2apyvypytwl6bOj_7TpobkXHrtJwIsjYNHZro12cB7vubIseF2zxL0-cLe-g_m_A5g3Hy6Xl_gNxpCwUQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>198566123</pqid></control><display><type>article</type><title>Association of T‐786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease</title><source>Wiley</source><creator>Sharan, K. ; Surrey, S. ; Ballas, S. ; Borowski, M. ; Devoto, M. ; Wang, K.‐F. ; Sandler, E. ; Keller, M.</creator><creatorcontrib>Sharan, K. ; Surrey, S. ; Ballas, S. ; Borowski, M. ; Devoto, M. ; Wang, K.‐F. ; Sandler, E. ; Keller, M.</creatorcontrib><description>Summary
Acute chest syndrome (ACS) is a life‐threatening complication of sickle cell disease (SCD). A retrospective study was performed to evaluate the role of endothelial nitric oxide synthase (eNOS) gene polymorphisms (E298D and T‐786C) in African–American SCD patients. The D298 allele showed no association; the C‐786 allele showed a statistically significant association (P = 0·0061) in female ACS cases. Multiple logistic regression analysis showed that relative risk of ACS was 8·695 (P = 0·0076, 95% confidence interval 1·761–42·920) for female carriers of C‐786. eNOS T‐786C is a gender‐specific genetic modifier that is associated with increased susceptibility to ACS in female SCD patients.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.2003.04762.x</identifier><identifier>PMID: 14687036</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>acute chest syndrome ; Acute Disease ; Adolescent ; Adult ; Aged ; Anemia, Sickle Cell - genetics ; Anemias. Hemoglobinopathies ; Biological and medical sciences ; Chest Pain - genetics ; Diseases of red blood cells ; Female ; genetic modifier ; Genetic Predisposition to Disease ; Genotype ; Hematologic and hematopoietic diseases ; Hematology ; Humans ; Male ; Medical sciences ; Middle Aged ; nitric oxide ; Nitric Oxide Synthase - genetics ; Nitric Oxide Synthase Type III ; polymorphism ; Polymorphism, Genetic - genetics ; Retrospective Studies ; Sequence Analysis, DNA ; Sickle cell anemia ; sickle cell disease ; Syndrome</subject><ispartof>British journal of haematology, 2004-01, Vol.124 (2), p.240-243</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Jan 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4722-22c4001a8ecaee477c15b01476ee14967d9c7e3885dcad756d34b73c920093d43</citedby><cites>FETCH-LOGICAL-c4722-22c4001a8ecaee477c15b01476ee14967d9c7e3885dcad756d34b73c920093d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15521990$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14687036$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharan, K.</creatorcontrib><creatorcontrib>Surrey, S.</creatorcontrib><creatorcontrib>Ballas, S.</creatorcontrib><creatorcontrib>Borowski, M.</creatorcontrib><creatorcontrib>Devoto, M.</creatorcontrib><creatorcontrib>Wang, K.‐F.</creatorcontrib><creatorcontrib>Sandler, E.</creatorcontrib><creatorcontrib>Keller, M.</creatorcontrib><title>Association of T‐786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
Acute chest syndrome (ACS) is a life‐threatening complication of sickle cell disease (SCD). A retrospective study was performed to evaluate the role of endothelial nitric oxide synthase (eNOS) gene polymorphisms (E298D and T‐786C) in African–American SCD patients. The D298 allele showed no association; the C‐786 allele showed a statistically significant association (P = 0·0061) in female ACS cases. Multiple logistic regression analysis showed that relative risk of ACS was 8·695 (P = 0·0076, 95% confidence interval 1·761–42·920) for female carriers of C‐786. eNOS T‐786C is a gender‐specific genetic modifier that is associated with increased susceptibility to ACS in female SCD patients.</description><subject>acute chest syndrome</subject><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anemia, Sickle Cell - genetics</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Biological and medical sciences</subject><subject>Chest Pain - genetics</subject><subject>Diseases of red blood cells</subject><subject>Female</subject><subject>genetic modifier</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>nitric oxide</subject><subject>Nitric Oxide Synthase - genetics</subject><subject>Nitric Oxide Synthase Type III</subject><subject>polymorphism</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Retrospective Studies</subject><subject>Sequence Analysis, DNA</subject><subject>Sickle cell anemia</subject><subject>sickle cell disease</subject><subject>Syndrome</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqNkUFv1DAQhS0EotvCX0AWEtwS7NixkwOHsqIUVNED5Wx5nQnrJYkXT6I2N44c-Y38Ehx2RSVOnMbSfO_pjR8hlLOcM6le7XIuVJkVXPK8YEzkTGpV5HcPyOrv4iFZMcZ0lgTVCTlF3DHGBSv5Y3LCpao0E2pFfpwjBuft6MNAQ0tvfn3_qSu1pvDx-hP9AgPQfejmPsT91mNPb_24pX5wESxCQ3FCB_vRb3znx5mOgVo3jUDdFnCkOA9NDD0kAW2htx3gwQC9-9olCrqONh4XryfkUWs7hKfHeUY-X7y9WV9mV9fv3q_PrzIndVFkReFkusNW4CyA1NrxcsN4Oh-Ay1rppnYaRFWVjbONLlUj5EYLV6dvqkUjxRl5efDdx_BtSilN73EJYgcIE5qKMVVKoRL4_B9wF6Y4pGyG11WpFC9EgqoD5GJAjNCaffS9jbPhzCxVmZ1ZGjFLI2apyvypytwl6bOj_7TpobkXHrtJwIsjYNHZro12cB7vubIseF2zxL0-cLe-g_m_A5g3Hy6Xl_gNxpCwUQ</recordid><startdate>200401</startdate><enddate>200401</enddate><creator>Sharan, K.</creator><creator>Surrey, S.</creator><creator>Ballas, S.</creator><creator>Borowski, M.</creator><creator>Devoto, M.</creator><creator>Wang, K.‐F.</creator><creator>Sandler, E.</creator><creator>Keller, M.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200401</creationdate><title>Association of T‐786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease</title><author>Sharan, K. ; Surrey, S. ; Ballas, S. ; Borowski, M. ; Devoto, M. ; Wang, K.‐F. ; Sandler, E. ; Keller, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4722-22c4001a8ecaee477c15b01476ee14967d9c7e3885dcad756d34b73c920093d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>acute chest syndrome</topic><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anemia, Sickle Cell - genetics</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Biological and medical sciences</topic><topic>Chest Pain - genetics</topic><topic>Diseases of red blood cells</topic><topic>Female</topic><topic>genetic modifier</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>nitric oxide</topic><topic>Nitric Oxide Synthase - genetics</topic><topic>Nitric Oxide Synthase Type III</topic><topic>polymorphism</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Retrospective Studies</topic><topic>Sequence Analysis, DNA</topic><topic>Sickle cell anemia</topic><topic>sickle cell disease</topic><topic>Syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharan, K.</creatorcontrib><creatorcontrib>Surrey, S.</creatorcontrib><creatorcontrib>Ballas, S.</creatorcontrib><creatorcontrib>Borowski, M.</creatorcontrib><creatorcontrib>Devoto, M.</creatorcontrib><creatorcontrib>Wang, K.‐F.</creatorcontrib><creatorcontrib>Sandler, E.</creatorcontrib><creatorcontrib>Keller, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharan, K.</au><au>Surrey, S.</au><au>Ballas, S.</au><au>Borowski, M.</au><au>Devoto, M.</au><au>Wang, K.‐F.</au><au>Sandler, E.</au><au>Keller, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of T‐786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2004-01</date><risdate>2004</risdate><volume>124</volume><issue>2</issue><spage>240</spage><epage>243</epage><pages>240-243</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Summary
Acute chest syndrome (ACS) is a life‐threatening complication of sickle cell disease (SCD). A retrospective study was performed to evaluate the role of endothelial nitric oxide synthase (eNOS) gene polymorphisms (E298D and T‐786C) in African–American SCD patients. The D298 allele showed no association; the C‐786 allele showed a statistically significant association (P = 0·0061) in female ACS cases. Multiple logistic regression analysis showed that relative risk of ACS was 8·695 (P = 0·0076, 95% confidence interval 1·761–42·920) for female carriers of C‐786. eNOS T‐786C is a gender‐specific genetic modifier that is associated with increased susceptibility to ACS in female SCD patients.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>14687036</pmid><doi>10.1046/j.1365-2141.2003.04762.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1048 |
| ispartof | British journal of haematology, 2004-01, Vol.124 (2), p.240-243 |
| issn | 0007-1048 1365-2141 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80065436 |
| source | Wiley |
| subjects | acute chest syndrome Acute Disease Adolescent Adult Aged Anemia, Sickle Cell - genetics Anemias. Hemoglobinopathies Biological and medical sciences Chest Pain - genetics Diseases of red blood cells Female genetic modifier Genetic Predisposition to Disease Genotype Hematologic and hematopoietic diseases Hematology Humans Male Medical sciences Middle Aged nitric oxide Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type III polymorphism Polymorphism, Genetic - genetics Retrospective Studies Sequence Analysis, DNA Sickle cell anemia sickle cell disease Syndrome |
| title | Association of T‐786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T18%3A47%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20T%E2%80%90786C%20eNOS%20gene%20polymorphism%20with%20increased%20susceptibility%20to%20acute%20chest%20syndrome%20in%20females%20with%20sickle%20cell%20disease&rft.jtitle=British%20journal%20of%20haematology&rft.au=Sharan,%20K.&rft.date=2004-01&rft.volume=124&rft.issue=2&rft.spage=240&rft.epage=243&rft.pages=240-243&rft.issn=0007-1048&rft.eissn=1365-2141&rft.coden=BJHEAL&rft_id=info:doi/10.1046/j.1365-2141.2003.04762.x&rft_dat=%3Cproquest_cross%3E80065436%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4722-22c4001a8ecaee477c15b01476ee14967d9c7e3885dcad756d34b73c920093d43%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=198566123&rft_id=info:pmid/14687036&rfr_iscdi=true |