CRITICAL VOLUME FOR PULMONARY ACID ASPIRATION: REAPPRAISAL IN A PRIMATE MODEL

We have studied, in the monkey, the critical volume for the production of severe pneumonitis following pulmonary aspiration of gastric contents. Aspiration of 0.4 ml kg−1 and 0.6 ml kg−1 at pH 1 produced mild to moderate clinical and radiological changes, but no deaths. Aspiration of 0.8 ml kg−1 and...

Full description

Saved in:
Bibliographic Details
Published in:British journal of anaesthesia : BJA 1990-08, Vol.65 (2), p.248-250
Main Authors: RAIDOO, D.M., ROCKE, D.A., BROCK-UTNE, J.G., MARSZALEK, A., ENGELBRECHT, H.E.
Format: Article
Language:English
Subjects:
Anaesthesia: obstetric
Animals
Biological and medical sciences
Cercopithecus aethiops
Complications: pulmonary aspiration
Disease Models, Animal
Gastric Acid
Heart Rate
Hydrogen-Ion Concentration
Medical sciences
Pneumology
Pneumonia, Aspiration - etiology
Pneumonia, Aspiration - physiopathology
Respiration
Respiratory system : syndromes and miscellaneous diseases
Time Factors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have studied, in the monkey, the critical volume for the production of severe pneumonitis following pulmonary aspiration of gastric contents. Aspiration of 0.4 ml kg−1 and 0.6 ml kg−1 at pH 1 produced mild to moderate clinical and radiological changes, but no deaths. Aspiration of 0.8 ml kg−1 and 1.0 ml kg−1 at pH 1 was associated with an increasingly severe pneumonitis. At 1.0 ml kg−1, 50% of the animals died—a mortality rate considerably less than that reported previously in animal studies. If these results were to be extrapolated to humans, the critical volume for severe aspiration could be increased from 25 ml to 50 ml (0.8 ml kg−1), considerably reducing the percentage of patients perceived to be “at risk”.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/65.2.248