EFFECT OF PROPOFOL ON PERIPHERAL VASCULAR RESISTANCE DURING CARDIOPULMONARY BYPASS

Twenty-eight patients undergoing elective coronary artery bypass surgery were allocated randomly to receive either propofol 2mg kg−1 or an equivalent volume of its vehicle during cardiopulmonary bypass with constant pump flow. Peripheral vascular resistance (PVR) was calculated from perfusion pressu...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1990-08, Vol.65 (2), p.184-189
Main Authors: BOER, F., ROS, P., BOVILL, J.G., VAN BRUMMELEN, P., VAN DER KROGT, J.
Format: Article
Language:English
Subjects:
Aged
Anaesthetics intravenous: propofol
Anesthesia, Intravenous
blood concentration
Cardiopulmonary Bypass
Coronary Artery Bypass
Double-Blind Method
Humans
Middle Aged
Propofol - administration & dosage
Propofol - blood
Propofol - pharmacology
Surgery: coronary artery
Time Factors
Vascular Resistance - drug effects
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Summary:Twenty-eight patients undergoing elective coronary artery bypass surgery were allocated randomly to receive either propofol 2mg kg−1 or an equivalent volume of its vehicle during cardiopulmonary bypass with constant pump flow. Peripheral vascular resistance (PVR) was calculated from perfusion pressure and pump flow. After propofol, PVR decreased from 1767 (SD 415) dyn s cm−5 to a minimum of 1263 (283) dyn s cm−5 at 2 min, and remained significantly less than the control value until 12.5 min after administration of propofol. In the group given the vehicle, PVR did not change significantly. In a second study in 10 patients, venous blood samples were withdrawn before and 2, 4, 6, 8, 10, 20 and 30 min after injection of propofol 2 mg kg−1 during cardiopulmonary bypass, for measurement of blood concentrations of propofol. Concentrations were greater than predicted by a computer simulation based on published pharmacokinetic data. The decrease in PVR may be an important factor in the hypotension caused by propofol during induction of anaesthesia.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/65.2.184