Pyridines and Pyrimidines Mediating Activity against an Efflux-Negative Strain of Candida albicans through Putative Inhibition of Lanosterol Demethylase

• Published in: Antimicrobial Agents and Chemotherapy 2004-01, Vol.48 (1), p.313-318
• Main Authors: BUURMAN, Ed T, BLODGETT, April E, HULL, Kenneth G, CARCANAGUE, Daniel
• Format: Article
• Language: English
• Subjects: Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal Agents; Antifungal Agents - chemical synthesis; Antifungal Agents - pharmacology; Biological and medical sciences; Candida albicans; Candida albicans - drug effects; Candida albicans - enzymology; Cdr1 protein; Cdr2 protein; Culture Media; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Enzyme Inhibitors - pharmacology; ergosterol; Fluconazole - pharmacology; Genes, Reporter - genetics; lanosterol demethylase; Mechanisms of Action: Physiological Effects; Medical sciences; Microbial Sensitivity Tests; Naphthalenes - pharmacology; Oxidoreductases; Oxidoreductases - antagonists & inhibitors; Pharmacology. Drug treatments; Pyridines; Pyridines - chemical synthesis; Pyridines - pharmacology; Pyrimidines; Pyrimidines - chemical synthesis; Pyrimidines - pharmacology; Sterol 14-Demethylase; Sterols - metabolism; Terbinafine
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.48.1.313-318.2004

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