Hypersensitivity of the Adrenal Cortex to Trophic and Secretory Effects of Angiotensin II in Lyon Genetically-Hypertensive Rats

• Published in: Hypertension (Dallas, Tex. 1979) Tex. 1979), 2004-01, Vol.43 (1), p.87-93
• Main Authors: Aguilar, Frédérick, Lo, Ming, Claustrat, Bruno, Saez, José Maria, Sassard, Jean, Li, Jacques Yuan
• Format: Article
• Language: English
• Subjects: Adrenal Cortex - drug effects; Adrenal Cortex - pathology; Adrenal Cortex - secretion; Adrenal Glands - drug effects; Adrenal Glands - pathology; Aldosterone - blood; Angiotensin II - pharmacology; Animals; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure - drug effects; Cardiology. Vascular system; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Corticosterone - blood; Experimental diseases; Hypertension - genetics; Hypertension - metabolism; Hypertension - pathology; Male; Medical sciences; Organ Size; Rats; Rats, Mutant Strains; Receptor, Angiotensin, Type 1 - metabolism; Receptor, Angiotensin, Type 2 - metabolism
• ISSN: 0194-911X; 1524-4563
• DOI: 10.1161/01.HYP.0000107194.44040.d4

ABSTRACT—In Lyon hypertensive (LH) rats, a model of low-renin genetic hypertension, we investigated adrenal sensitivity to angiotensin II in terms of angiotensin II receptor (AT1 and AT2 receptors) regulation, morphological changes, and aldosterone and corticosterone secretion. Twelve-week-old LH rats, compared with normotensive LN and LL rats, were either untreated or treated for 4 weeks with AT1 receptor antagonist irbesartan (50 mg/kg/d), angiotensin-converting enzyme inhibitor perindopril (3 mg/kg/d), or perindopril (3 mg/kg/d) plus angiotensin II infusion (200 ng/kg/min). At 16 weeks, untreated LH rats had high systolic blood pressure (P