Increased vasoconstrictor response to noradrenaline in femoral vascular bed of diabetic dogs. Is thromboxane A2 involved?

• Published in: Cardiovascular research 1990-09, Vol.24 (9), p.707-710
• Main Authors: Koltai, Mária Zsófia, Rösen, Peter, Ballagi-Pordány, György, Hadházy, Pál, Pogátsa, Gábor
• Format: Article
• Language: English
• Subjects: Animals; Aspirin - pharmacology; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - physiopathology; Dogs; Dose-Response Relationship, Drug; Epoprostenol - biosynthesis; experimental diabetes; Female; Femoral Vein - drug effects; Femoral Vein - metabolism; Femoral Vein - physiopathology; hind limb circulation; hyperreactivity to noradrenaline; Indomethacin - pharmacology; Male; Norepinephrine - pharmacology; Organ Culture Techniques; Phentolamine - pharmacology; thromboxane A2; Thromboxane A2 - biosynthesis; Vasoconstriction - drug effects; α adrenoceptors
• ISSN: 0008-6363; 1755-3245
• DOI: 10.1093/cvr/24.9.707

Study objective – The aim was to determine the role of cyclo-oxygenase products in the vasoconstrictor response of femoral arterial bed to noradrenaline and to analyse the role of vascular adrenoceptors in the synthesis of cyclo-oxygenase products. Design – The influence of intra-arterially injected cyclo-oxygenase inhibitors indomethacin and acetylsalicylic acid on alterations in conductance of femoral arterial bed induced by noradrenaline was compared in metabolically healthy and alloxan diabetic dogs. PGI2 and TXA2 synthesising ability of isolated femoral arterial rings was measured with and without inhibition of α adrenoceptors by phentolamine. Subjects – 18 metabolically healthy and 18 alloxan (560 μmol·kg−1) diabetic dogs of either sex, weight 16–28 kg, were studied. Measurements and main results – Noradrenaline produced greater (p