Chemical Strategies for Activity-Based Proteomics

The assignment of molecular and cellular functions to the numerous protein products encoded by prokaryotic and eukaryotic genomes presents a major challenge for the field of proteomics. To address this problem, chemical approaches have been introduced that utilize small-molecule probes to profile dy...

Full description

Saved in:
Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2004-01, Vol.5 (1), p.41-47
Main Authors: Speers, Anna E, Cravatt, Benjamin F
Format: Article
Language:English
Subjects:
activity-based profiling
Animals
Drug Delivery Systems
Drug Design
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
enzymes
Enzymes - chemistry
Humans
inhibitors
probes
Protein Engineering
proteomics
Proteomics - methods
Structure-Activity Relationship
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The assignment of molecular and cellular functions to the numerous protein products encoded by prokaryotic and eukaryotic genomes presents a major challenge for the field of proteomics. To address this problem, chemical approaches have been introduced that utilize small-molecule probes to profile dynamics in enzyme activity in complex proteomes. These strategies for activity-based protein profiling enable both the discovery and functional analysis of enzymes associated with human disease.
ISSN:1439-4227
1439-7633
1439-4227
DOI:10.1002/cbic.200300721