The swelling properties of hydroxypropyl methyl cellulose loaded with tetracycline hydrochloride: magnetic resonance imaging study

Magnetic resonance imaging was used to study the behavior of the gel layer thickness in hydroxypropyl methyl cellulose (HPMC) matrices loaded with different amounts of soluble tetracycline hydrochloride. The time dependence of the diffusion front, effective T 2, and proton-density analysis clearly i...

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Bibliographic Details
Published in:Solid state nuclear magnetic resonance 2004, Vol.25 (1), p.35-41
Main Authors: Kowalczuk, Joanna, Tritt-Goc, Jadwiga, Piślewski, Narcyz
Format: Article
Language:English
Subjects:
Case II diffusion
Crystallography - methods
Diffusion
Effective spin–spin map
Gels - chemistry
Hydroxypropyl methyl cellulose
Hypromellose Derivatives
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Methylcellulose - analogs & derivatives
Methylcellulose - chemistry
Molecular Conformation
Osmotic Pressure
Proton density map
Solutions
Solvents - chemistry
Swelling
Tetracycline - chemistry
Tetracycline hydrochloride
Water - chemistry
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Summary:Magnetic resonance imaging was used to study the behavior of the gel layer thickness in hydroxypropyl methyl cellulose (HPMC) matrices loaded with different amounts of soluble tetracycline hydrochloride. The time dependence of the diffusion front, effective T 2, and proton-density analysis clearly indicates a Case II diffusion mechanism in the system composed of water solution of hydrochloric acid (pH=2) and HPMC. The solvent penetration front was used to describe the swelling properties as well as the integrity of the HPMC matrices. The results show that the tetracycline hydrochloride decreases the resistance of the HPMC network structure against the movement of solvent molecules. On the other hand the swelling properties of the matrix increase with the amount of drug in the matrix.
ISSN:0926-2040
1527-3326
DOI:10.1016/j.ssnmr.2003.03.016