Mouse Cellular Cementum is Highly Dependent on Growth Hormone Status

Cementum is known to be growth-hormone (GH)-responsive, but to what extent is unclear. This study examines the effects of extremes of GH status on cementogenesis in three lines of genetically modified mice; GH excess (giant), GH antagonist excess (dwarf), and GH receptor-deleted (GHR-KO) (dwarf). Ag...

Full description

Saved in:
Bibliographic Details
Published in:Journal of dental research 2004-01, Vol.83 (1), p.35-39
Main Authors: Smid, J.R., Rowland, J.E., Young, W.G., Daley, T.J., Coschigano, K.T., Kopchick, J.J., Waters, M.J.
Format: Article
Language:English
Subjects:
Animals
Cementogenesis - physiology
Dental Cementum - pathology
Dentistry
Dwarfism - genetics
Dwarfism - physiopathology
Female
Gigantism - genetics
Gigantism - physiopathology
Growth Hormone - physiology
Image Processing, Computer-Assisted
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred Strains
Mice, Knockout
Mice, Transgenic
Molar - pathology
Odontometry
Phenotype
Receptors, Somatotropin - genetics
Receptors, Somatotropin - physiology
Tooth Root - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cementum is known to be growth-hormone (GH)-responsive, but to what extent is unclear. This study examines the effects of extremes of GH status on cementogenesis in three lines of genetically modified mice; GH excess (giant), GH antagonist excess (dwarf), and GH receptor-deleted (GHR-KO) (dwarf). Age-matched mandibular molar tissues were processed for light microscope histology. Digital images of sections of first molar teeth were captured for morphometric analysis of lingual root cementum. Cross-sectional area of the cellular cementum was a sensitive guide to GH status, being reduced nearly 10-fold in GHR-KO mice, three-fold in GH antagonist mice, and increased almost two-fold in giant mice (p < 0.001). Cellular cementum length was similarly influenced by GH status, but to a lesser extent. Acellular cementum was generally unaffected. This study reveals cellular cementum to be a highly responsive GH target tissue, which may have therapeutic applications in assisting regeneration of the periodontium.
ISSN:0022-0345
1544-0591
DOI:10.1177/154405910408300107