Syntheses and radical scavenging activities of resveratrol derivatives

Nine new resveratrol derivatives, having bromo, iodo, and fluoroethyl groups, were designed and synthesized. All compounds having free phenol groups showed good free radical scavenging activity. Among them, 2-bromoresveratrol 19 has a similar free radical scavenging activity to (+)-catechin. Nine ne...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2004-01, Vol.14 (2), p.463-466
Main Authors: Lee, Hyun Jung, Seo, Jai Woong, Lee, Bong Ho, Chung, Kyoo-Hyun, Chi, Dae Yoon
Format: Article
Language:English
Subjects:
Antioxidant
Antioxidants - chemical synthesis
Antioxidants - metabolism
Biological and medical sciences
Free Radical Scavengers - chemical synthesis
Free Radical Scavengers - metabolism
General and cellular metabolism. Vitamins
Medical sciences
Pharmacology. Drug treatments
Phenol
Radical scavenger
Resveratrol
Stilbene
Stilbenes - chemical synthesis
Stilbenes - metabolism
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Summary:Nine new resveratrol derivatives, having bromo, iodo, and fluoroethyl groups, were designed and synthesized. All compounds having free phenol groups showed good free radical scavenging activity. Among them, 2-bromoresveratrol 19 has a similar free radical scavenging activity to (+)-catechin. Nine new resveratrol derivatives, were designed and synthesized. Among them, 2-bromoresveratrol 19 has a similar free radical scavenging activity to (+)-catechin.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2003.10.038