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Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues
Novel quinoxaline antibiotics having the methylenedithioether bridge as an analogue of echinomycin have been synthesized by insertion of methylene moiety between –S–S– bond. The compound 1a shows remarkable cytotoxicities against human tumor various cell lines, and is active VRE (vancomycin-resistan...
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| Published in: | Bioorganic & medicinal chemistry letters 2004-01, Vol.14 (2), p.541-544 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c382t-6190152e17e9d1ab1f8665088242a7c5472ddfce15ce4fd9320ef7328eba14363 |
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| cites | cdi_FETCH-LOGICAL-c382t-6190152e17e9d1ab1f8665088242a7c5472ddfce15ce4fd9320ef7328eba14363 |
| container_end_page | 544 |
| container_issue | 2 |
| container_start_page | 541 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 14 |
| creator | Kim, Yun Bong Kim, Yong Hae Park, Ju Youn Kim, Soo Kie |
| description | Novel quinoxaline antibiotics having the methylenedithioether bridge as an analogue of echinomycin have been synthesized by insertion of methylene moiety between –S–S– bond. The compound
1a shows remarkable cytotoxicities against human tumor various cell lines, and is active VRE (vancomycin-resistant enterococci) within MIC range 0.5–8 μg/mL. According to the eukaryotic or prokaryotic data,
1a might be a first analogue to replace echinomycin.
The novel compound
1a shows potential activities against various human cancer cell lines. |
| doi_str_mv | 10.1016/j.bmcl.2003.09.086 |
| format | article |
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1a shows remarkable cytotoxicities against human tumor various cell lines, and is active VRE (vancomycin-resistant enterococci) within MIC range 0.5–8 μg/mL. According to the eukaryotic or prokaryotic data,
1a might be a first analogue to replace echinomycin.
The novel compound
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1a shows remarkable cytotoxicities against human tumor various cell lines, and is active VRE (vancomycin-resistant enterococci) within MIC range 0.5–8 μg/mL. According to the eukaryotic or prokaryotic data,
1a might be a first analogue to replace echinomycin.
The novel compound
1a shows potential activities against various human cancer cell lines.</description><subject>Active-VRE</subject><subject>Anti-Bacterial Agents - chemical synthesis</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Anticancer</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - physiology</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Echinomycin</subject><subject>Echinomycin - analogs & derivatives</subject><subject>Echinomycin - chemical synthesis</subject><subject>Echinomycin - pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Miscellaneous. Antibiotics with multiple activities</subject><subject>Pharmacology. Drug treatments</subject><subject>Quinoxalines - chemical synthesis</subject><subject>Quinoxalines - pharmacology</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp9kE1P3DAQhq2qqGxp_0APVS7tLWH8EceWuCDUFiSkHgCJnizHmZRZJQ7EWWD_fb3albj1NIf3mXdGD2NfOFQcuD5dV-0YhkoAyApsBUa_YyuutCqlgvo9W4HVUBqr7o_Zx5TWAFyBUh_YcYas4dau2J-bbVweMFEqfOyKlqZh-kvBD4UPCz3Tsi2mvoj4UjxtKE6vfqCIGV0oowuFtIsxPORs3AaKOfK5YYPpEzvq_ZDw82GesLufP24vLsvr37-uLs6vyyCNWErNLfBaIG_Qdty3vDda12CMUMI3oVaN6Lo-IK8Dqr6zUgD2jRQGW8-V1PKEfd_3Ps7TU767uJFSwGHwEadNcgag0UKoDIo9GOYppRl79zjT6Oet4-B2Qt3a7YS6nVAH1mWheenroX3Tjti9rRwMZuDbAfApa-tnHwOlN66WJmuXmTvbc5hdPBPOLgXCGLCjGcPiuon-98c_j9mVHQ</recordid><startdate>20040119</startdate><enddate>20040119</enddate><creator>Kim, Yun Bong</creator><creator>Kim, Yong Hae</creator><creator>Park, Ju Youn</creator><creator>Kim, Soo Kie</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040119</creationdate><title>Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues</title><author>Kim, Yun Bong ; Kim, Yong Hae ; Park, Ju Youn ; Kim, Soo Kie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-6190152e17e9d1ab1f8665088242a7c5472ddfce15ce4fd9320ef7328eba14363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Active-VRE</topic><topic>Anti-Bacterial Agents - chemical synthesis</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Anticancer</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - physiology</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Echinomycin</topic><topic>Echinomycin - analogs & derivatives</topic><topic>Echinomycin - chemical synthesis</topic><topic>Echinomycin - pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Miscellaneous. Antibiotics with multiple activities</topic><topic>Pharmacology. Drug treatments</topic><topic>Quinoxalines - chemical synthesis</topic><topic>Quinoxalines - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Yun Bong</creatorcontrib><creatorcontrib>Kim, Yong Hae</creatorcontrib><creatorcontrib>Park, Ju Youn</creatorcontrib><creatorcontrib>Kim, Soo Kie</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Yun Bong</au><au>Kim, Yong Hae</au><au>Park, Ju Youn</au><au>Kim, Soo Kie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2004-01-19</date><risdate>2004</risdate><volume>14</volume><issue>2</issue><spage>541</spage><epage>544</epage><pages>541-544</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>Novel quinoxaline antibiotics having the methylenedithioether bridge as an analogue of echinomycin have been synthesized by insertion of methylene moiety between –S–S– bond. The compound
1a shows remarkable cytotoxicities against human tumor various cell lines, and is active VRE (vancomycin-resistant enterococci) within MIC range 0.5–8 μg/mL. According to the eukaryotic or prokaryotic data,
1a might be a first analogue to replace echinomycin.
The novel compound
1a shows potential activities against various human cancer cell lines.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>14698199</pmid><doi>10.1016/j.bmcl.2003.09.086</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (2), p.541-544 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Active-VRE Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Anticancer Apoptosis Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Cell Line, Tumor Echinomycin Echinomycin - analogs & derivatives Echinomycin - chemical synthesis Echinomycin - pharmacology Humans Medical sciences Miscellaneous. Antibiotics with multiple activities Pharmacology. Drug treatments Quinoxalines - chemical synthesis Quinoxalines - pharmacology |
| title | Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues |
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