Elucidating the role of nutraceuticals in overexpressing antiapoptotic proteins in prostate cancer

[...]several molecular mechanisms involved in the progression of cancer and the development of resistance to chemotherapy are associated with overexpression of Bcl-2. [...]the need exists for the discovery of novel Bcl-2 phosphorylating or repressing molecules.

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Bibliographic Details
Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2004, Vol.20 (1), p.78-82
Main Author: Rafi, Mohamed M
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Apoptosis
Apoptosis - genetics
Apoptosis - physiology
Cell cycle
Functional foods & nutraceuticals
Gene Expression Regulation, Neoplastic
Genes
Humans
Kinases
Male
Phosphorylation
Prostate cancer
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - genetics
Prostatic Neoplasms - metabolism
Proteins
Proto-Oncogene Proteins c-bcl-2 - genetics
Proto-Oncogene Proteins c-bcl-2 - metabolism
Tumor Cells, Cultured
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Description
Summary:[...]several molecular mechanisms involved in the progression of cancer and the development of resistance to chemotherapy are associated with overexpression of Bcl-2. [...]the need exists for the discovery of novel Bcl-2 phosphorylating or repressing molecules.
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2003.09.014