Molecular regulation of the life cycle of African trypanosomes

Preventing the transmission of African trypanosomes between mammalian hosts has been one of the most effective mechanisms to date for the control of these important parasites. Hence, understanding the mechanisms through which they control their life cycle in molecular terms could provide valuable st...

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Bibliographic Details
Published in:Trends in parasitology 2004, Vol.20 (1), p.40-47
Main Authors: Matthews, Keith R., Ellis, James R., Paterou, Athina
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Disease Transmission, Infectious
DNA, Protozoan - genetics
DNA, Protozoan - metabolism
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Gene Expression Regulation, Developmental
Humans
Life Cycle Stages - genetics
Life cycle. Host-agent relationship. Pathogenesis
Protozoa
RNA, Messenger - genetics
RNA, Messenger - metabolism
Trypanosoma - genetics
Trypanosoma - growth & development
Trypanosoma brucei
Trypanosomiasis, African - blood
Trypanosomiasis, African - parasitology
Trypanosomiasis, African - transmission
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Summary:Preventing the transmission of African trypanosomes between mammalian hosts has been one of the most effective mechanisms to date for the control of these important parasites. Hence, understanding the mechanisms through which they control their life cycle in molecular terms could provide valuable strategies for restricting the impact of sleeping sickness. Over the past two to three years, the study of the molecular cell biology of trypanosome life cycle progression has made considerable advances. Here, these advances are placed in the context of the biology of the parasite, to provide an integrated overview of developmental events in Trypanosoma brucei.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2003.10.016