Part I: Hodgkin's lymphoma—molecular biology of Hodgkin and Reed-Sternberg cells

Classic Hodgkin's lymphoma is characterised by Hodgkin and Reed-Sternberg cells and in most cases are derived from germinal-centre B cells. Despite progress in basic research showing the natural precursor cells of Hodgkin's lymphoma, most key questions still remain unanswered. Among these...

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Bibliographic Details
Published in:The lancet oncology 2004-01, Vol.5 (1), p.11-18
Main Authors: Thomas, Roman K, Re, Daniel, Wolf, Jürgen, Diehl, Volker
Format: Article
Language:English
Subjects:
Antigens
Apoptosis
Apoptosis - genetics
Cells
Cloning
Gene expression
Hodgkin Disease - classification
Hodgkin Disease - genetics
Hodgkin Disease - pathology
Humans
Immunoglobulins
Lymphocytes
Lymphoma
Molecular Biology
Mutation
NF-kappa B - metabolism
Reed-Sternberg Cells - pathology
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Summary:Classic Hodgkin's lymphoma is characterised by Hodgkin and Reed-Sternberg cells and in most cases are derived from germinal-centre B cells. Despite progress in basic research showing the natural precursor cells of Hodgkin's lymphoma, most key questions still remain unanswered. Among these are the basic transforming events, the involvement of oncogenic viruses, the mechanisms enabling Hodgkin and Reed Sternberg cells to resist apoptosis in the germinal centre, and the molecular causes of their characteristic phenotype. Beyond the disclosure of these issues, the detection of changes in gene expression, gene mutations, and chromosomal imbalances specific of Hodgkin's lymphoma are central to recent research that may allow one a better understanding of the natural history of this type of lymphoma.
ISSN:1470-2045
1474-5488
DOI:10.1016/S1470-2045(03)01319-6