Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions

Glycosphingolipids (GSLs), or their modified catabolites, at the cell surface modulate transmembrane signal transduction by influencing protein kinases associated with growth factor receptors and protein kinase C. On the other hand, the same or different GSLs at the cell surface interact in highly s...

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Bibliographic Details
Published in:The Journal of biological chemistry 1990-11, Vol.265 (31), p.18713-18716
Main Author: Hakomori, S
Format: Article
Language:English
Subjects:
Animals
Cell Communication
Cell Division
Cell Membrane - physiology
Gangliosides - physiology
Glycosphingolipids - physiology
Membrane Lipids - physiology
Models, Biological
reviews
Signal Transduction
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Summary:Glycosphingolipids (GSLs), or their modified catabolites, at the cell surface modulate transmembrane signal transduction by influencing protein kinases associated with growth factor receptors and protein kinase C. On the other hand, the same or different GSLs at the cell surface interact in highly specific fashion with other GSLs or with binding proteins, possibly at the surface of adjacent interacting cells or in the extracellular matrix. The GSL-GSL interaction apparently provides the basis for a specific cell recognition system independent of the fibronectin/integrin or surface lectin systems, occurring earlier during a cell recognition event.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(17)30565-3