Clinical and nutritional correlates of C-reactive protein in type 2 diabetic nephropathy

Background: Patients with diabetic nephropathy are at elevated cardiovascular risk. C-reactive protein (CRP) has been used to successfully predict cardiovascular events. Objective: We identified clinical and biochemical characteristics that correlate with CRP levels in diabetic nephropathy patients....

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Bibliographic Details
Published in:Atherosclerosis 2004, Vol.172 (1), p.121-125
Main Authors: Friedman, Allon N., Hunsicker, Lawrence G., Selhub, Jacob, Bostom, Andrew G.
Format: Article
Language:English
Subjects:
Adult
Aged
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Body Mass Index
C-reactive protein
C-Reactive Protein - analysis
Cardiology. Vascular system
Cardiovascular
Cardiovascular Diseases - etiology
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Creatinine
Creatinine - blood
Depsipeptides
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Diabetic Nephropathies - complications
Diabetic Nephropathies - metabolism
Female
Folic Acid - blood
Glycated Hemoglobin A - analogs & derivatives
Glycated Hemoglobin A - analysis
Humans
Male
Medical sciences
Middle Aged
Peptides, Cyclic - blood
Proteinuria
Pyridoxal phosphate
Pyridoxal Phosphate - blood
Risk Factors
Serum Albumin - analysis
Triglycerides - blood
Vitamin B 12 - blood
Vitamin B 6
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Summary:Background: Patients with diabetic nephropathy are at elevated cardiovascular risk. C-reactive protein (CRP) has been used to successfully predict cardiovascular events. Objective: We identified clinical and biochemical characteristics that correlate with CRP levels in diabetic nephropathy patients. Design: Baseline data obtained from 722 patients in the Irbesartan Diabetic Nephropathy Trial included age, sex, body mass index (BMI), systolic blood pressure (BP), serum creatinine, plasma low- and high-density cholesterol, triacylglycerol, serum albumin, hemoglobin A1C, 24 h urinary protein excretion, plasma total homocysteine (tHcy), folate, B12, pyridoxal 5′-phosphate (PLP, active form of Vitamin B 6), and plasma CRP levels. Results: In univariate analyses CRP was positively associated with female sex ( r=0.08; P=0.04), BMI ( r=0.34; P
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2003.09.011