Poly(N,N,N-trimethylammoniumalkyl acrylamide chloride) Based Hydrogels for Serum Cholesterol Reduction

• Published in: Biomacromolecules 2004-01, Vol.5 (1), p.24-31
• Main Authors: Cameron, Neil S, Morin, Frederick G, Eisenberg, Adi, Brown, G. Ronald
• Format: Article
• Language: English
• Subjects: Acrylic Resins - chemical synthesis; Acrylic Resins - therapeutic use; Applied sciences; Binding Sites; Cholesterol - blood; Cholesterol - metabolism; Exact sciences and technology; Glycocholic Acid - metabolism; Humans; Hydrogels - chemical synthesis; Hydrogels - therapeutic use; Hypercholesterolemia - drug therapy; Nanotechnology; Organic polymers; Particle Size; Physicochemistry of polymers; Properties and characterization; Quaternary Ammonium Compounds - chemical synthesis; Quaternary Ammonium Compounds - therapeutic use; Solution and gel properties; Spectrum Analysis
• ISSN: 1525-7797; 1526-4602
• DOI: 10.1021/bm034174v

Hydrogels present an attractive alternative to nanoscale block copolymer aggregates and microscale resin beads as potential asystemic serum cholesterol reduction materials. Not only would the oral delivery of these materials be more pleasant than the sand-like bile salt anion sequestrant beads but also the hydrogel preparation is much simpler than the copolymer aggregate analogues [Cameron, N. S.; Eisenberg, A.; Brown, G. R. Biomacromolecules 2002, 3, 116−123. Cameron, N. S.; Eisenberg, A.; Brown, G. R. Biomacromolecules 2002, 3, 124−132]. , Our goal was to explore these materials building on our experience with bulk resins and self-assembled copolymers. In this paper, following a brief introduction to hydrogels and their application to hypercholesterolemia, the synthesis, characterization, and preliminary glycocholate binding properties of poly(N,N,N-trimethylammoniumalkyl acrylamide chloride)gel are presented [Cameron, N. S.; Eisenberg, A.; Brown, G. R. Polym. Preprints 2002, 43, 771−772].