Bioartificial Pancreas Research in Japan

:  The bioartificial pancreas (BAP), a medical device enclosing insulin‐secreting cells in a semipermeable membrane, is expected to physiologically control glucose levels, and thus to be able to inhibit development of serious chronic complications in diabetic patients. In this brief review, we intro...

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Bibliographic Details
Published in:Artificial organs 2004-01, Vol.28 (1), p.45-52
Main Authors: Iwata, Hiroo, Simada, Hideki, Fukuma, Eisai, Ibii, Takahisa, Sato, Hideki
Format: Article
Language:English
Subjects:
Animals
Bioartificial pancreas
Cell Differentiation
Diabetes
Diabetes Mellitus, Type 1 - therapy
Embryo, Mammalian - cytology
Equipment Design
Humans
Immunoisolation
Insulin - metabolism
Insulin Secretion
Insulin-secreting cells
Islet of Langerhans
Islets of Langerhans Transplantation
Japan
Mice
Pancreas
Pancreas, Artificial
Semipermeable membrane
Stem Cells - cytology
Tissue engineering
Transplantation
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Summary::  The bioartificial pancreas (BAP), a medical device enclosing insulin‐secreting cells in a semipermeable membrane, is expected to physiologically control glucose levels, and thus to be able to inhibit development of serious chronic complications in diabetic patients. In this brief review, we introduce research activities on the development of the BAP in Japan, including membrane preparation for the BAP, evaluation of in vitro and in vivo BAP functions, and challenges for production of insulin‐secreting  cells  from  stem  cells.
ISSN:0160-564X
1525-1594
DOI:10.1111/j.1525-1594.2004.07322.x