Loading…

Bioartificial Pancreas Research in Japan

: The bioartificial pancreas (BAP), a medical device enclosing insulin‐secreting cells in a semipermeable membrane, is expected to physiologically control glucose levels, and thus to be able to inhibit development of serious chronic complications in diabetic patients. In this brief review, we intro...

Full description

Saved in:

Bibliographic Details
Published in:	Artificial organs 2004-01, Vol.28 (1), p.45-52
Main Authors:	Iwata, Hiroo, Simada, Hideki, Fukuma, Eisai, Ibii, Takahisa, Sato, Hideki
Format:	Article
Language:	English
Subjects:	Animals Bioartificial pancreas Cell Differentiation Diabetes Diabetes Mellitus, Type 1 - therapy Embryo, Mammalian - cytology Equipment Design Humans Immunoisolation Insulin - metabolism Insulin Secretion Insulin-secreting cells Islet of Langerhans Islets of Langerhans Transplantation Japan Mice Pancreas Pancreas, Artificial Semipermeable membrane Stem Cells - cytology Tissue engineering Transplantation
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c4782-ff03a441f0790795c5b2bfde48a76b7f3384edfc62cdc2f9bee53f3843afc7493
cites	cdi_FETCH-LOGICAL-c4782-ff03a441f0790795c5b2bfde48a76b7f3384edfc62cdc2f9bee53f3843afc7493
container_end_page	52
container_issue	1
container_start_page	45
container_title	Artificial organs
container_volume	28
creator	Iwata, Hiroo Simada, Hideki Fukuma, Eisai Ibii, Takahisa Sato, Hideki
description	: The bioartificial pancreas (BAP), a medical device enclosing insulin‐secreting cells in a semipermeable membrane, is expected to physiologically control glucose levels, and thus to be able to inhibit development of serious chronic complications in diabetic patients. In this brief review, we introduce research activities on the development of the BAP in Japan, including membrane preparation for the BAP, evaluation of in vitro and in vivo BAP functions, and challenges for production of insulin‐secreting cells from stem cells.
doi_str_mv	10.1111/j.1525-1594.2004.07322.x
format	article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80091624</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80091624</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4782-ff03a441f0790795c5b2bfde48a76b7f3384edfc62cdc2f9bee53f3843afc7493</originalsourceid><addsrcrecordid>eNqNkF1LwzAUhoMoOqd_QXol3rSefDXthRcqfo3pZCruLqRZgpldN5MNt39va4deajiQw8nznsCDUIQhwfU5nSSYEx5jnrOEALAEBCUkWW2hzs_DNuoATiHmKRvtof0QJgAgGKS7aA8zQYBkWQedXLiZ8gtnnXaqjB5Vpb1RIRqaYJTXb5Grop6aq-oA7VhVBnO4ubvo5frq-fI27g9u7i7P-7FmIiOxtUAVY9iCyOvimheksGPDMiXSQlhKM2bGVqdEjzWxeWEMp7YeUmW1YDntouN279zPPpYmLOTUBW3KUlVmtgwyA8hxStifIBaCsyyFGsxaUPtZCN5YOfduqvxaYpCNTjmRjTXZWJONTvmtU67q6NHmj2UxNePf4MZfDZy1wKcrzfrfi-X5YNh0dT5u8y4szOonr_y7TAUVXL4-3Ej-9NC7H416sk-_AM2dkXA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17754860</pqid></control><display><type>article</type><title>Bioartificial Pancreas Research in Japan</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Iwata, Hiroo ; Simada, Hideki ; Fukuma, Eisai ; Ibii, Takahisa ; Sato, Hideki</creator><creatorcontrib>Iwata, Hiroo ; Simada, Hideki ; Fukuma, Eisai ; Ibii, Takahisa ; Sato, Hideki</creatorcontrib><description>: The bioartificial pancreas (BAP), a medical device enclosing insulin‐secreting cells in a semipermeable membrane, is expected to physiologically control glucose levels, and thus to be able to inhibit development of serious chronic complications in diabetic patients. In this brief review, we introduce research activities on the development of the BAP in Japan, including membrane preparation for the BAP, evaluation of in vitro and in vivo BAP functions, and challenges for production of insulin‐secreting cells from stem cells.</description><identifier>ISSN: 0160-564X</identifier><identifier>EISSN: 1525-1594</identifier><identifier>DOI: 10.1111/j.1525-1594.2004.07322.x</identifier><identifier>PMID: 14720288</identifier><language>eng</language><publisher>Oxford, UK and Malden, USA: Blackwell Science Inc</publisher><subject>Animals ; Bioartificial pancreas ; Cell Differentiation ; Diabetes ; Diabetes Mellitus, Type 1 - therapy ; Embryo, Mammalian - cytology ; Equipment Design ; Humans ; Immunoisolation ; Insulin - metabolism ; Insulin Secretion ; Insulin-secreting cells ; Islet of Langerhans ; Islets of Langerhans Transplantation ; Japan ; Mice ; Pancreas ; Pancreas, Artificial ; Semipermeable membrane ; Stem Cells - cytology ; Tissue engineering ; Transplantation</subject><ispartof>Artificial organs, 2004-01, Vol.28 (1), p.45-52</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4782-ff03a441f0790795c5b2bfde48a76b7f3384edfc62cdc2f9bee53f3843afc7493</citedby><cites>FETCH-LOGICAL-c4782-ff03a441f0790795c5b2bfde48a76b7f3384edfc62cdc2f9bee53f3843afc7493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14720288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iwata, Hiroo</creatorcontrib><creatorcontrib>Simada, Hideki</creatorcontrib><creatorcontrib>Fukuma, Eisai</creatorcontrib><creatorcontrib>Ibii, Takahisa</creatorcontrib><creatorcontrib>Sato, Hideki</creatorcontrib><title>Bioartificial Pancreas Research in Japan</title><title>Artificial organs</title><addtitle>Artif Organs</addtitle><description>: The bioartificial pancreas (BAP), a medical device enclosing insulin‐secreting cells in a semipermeable membrane, is expected to physiologically control glucose levels, and thus to be able to inhibit development of serious chronic complications in diabetic patients. In this brief review, we introduce research activities on the development of the BAP in Japan, including membrane preparation for the BAP, evaluation of in vitro and in vivo BAP functions, and challenges for production of insulin‐secreting cells from stem cells.</description><subject>Animals</subject><subject>Bioartificial pancreas</subject><subject>Cell Differentiation</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - therapy</subject><subject>Embryo, Mammalian - cytology</subject><subject>Equipment Design</subject><subject>Humans</subject><subject>Immunoisolation</subject><subject>Insulin - metabolism</subject><subject>Insulin Secretion</subject><subject>Insulin-secreting cells</subject><subject>Islet of Langerhans</subject><subject>Islets of Langerhans Transplantation</subject><subject>Japan</subject><subject>Mice</subject><subject>Pancreas</subject><subject>Pancreas, Artificial</subject><subject>Semipermeable membrane</subject><subject>Stem Cells - cytology</subject><subject>Tissue engineering</subject><subject>Transplantation</subject><issn>0160-564X</issn><issn>1525-1594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqNkF1LwzAUhoMoOqd_QXol3rSefDXthRcqfo3pZCruLqRZgpldN5MNt39va4deajiQw8nznsCDUIQhwfU5nSSYEx5jnrOEALAEBCUkWW2hzs_DNuoATiHmKRvtof0QJgAgGKS7aA8zQYBkWQedXLiZ8gtnnXaqjB5Vpb1RIRqaYJTXb5Grop6aq-oA7VhVBnO4ubvo5frq-fI27g9u7i7P-7FmIiOxtUAVY9iCyOvimheksGPDMiXSQlhKM2bGVqdEjzWxeWEMp7YeUmW1YDntouN279zPPpYmLOTUBW3KUlVmtgwyA8hxStifIBaCsyyFGsxaUPtZCN5YOfduqvxaYpCNTjmRjTXZWJONTvmtU67q6NHmj2UxNePf4MZfDZy1wKcrzfrfi-X5YNh0dT5u8y4szOonr_y7TAUVXL4-3Ej-9NC7H416sk-_AM2dkXA</recordid><startdate>200401</startdate><enddate>200401</enddate><creator>Iwata, Hiroo</creator><creator>Simada, Hideki</creator><creator>Fukuma, Eisai</creator><creator>Ibii, Takahisa</creator><creator>Sato, Hideki</creator><general>Blackwell Science Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200401</creationdate><title>Bioartificial Pancreas Research in Japan</title><author>Iwata, Hiroo ; Simada, Hideki ; Fukuma, Eisai ; Ibii, Takahisa ; Sato, Hideki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4782-ff03a441f0790795c5b2bfde48a76b7f3384edfc62cdc2f9bee53f3843afc7493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Bioartificial pancreas</topic><topic>Cell Differentiation</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - therapy</topic><topic>Embryo, Mammalian - cytology</topic><topic>Equipment Design</topic><topic>Humans</topic><topic>Immunoisolation</topic><topic>Insulin - metabolism</topic><topic>Insulin Secretion</topic><topic>Insulin-secreting cells</topic><topic>Islet of Langerhans</topic><topic>Islets of Langerhans Transplantation</topic><topic>Japan</topic><topic>Mice</topic><topic>Pancreas</topic><topic>Pancreas, Artificial</topic><topic>Semipermeable membrane</topic><topic>Stem Cells - cytology</topic><topic>Tissue engineering</topic><topic>Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iwata, Hiroo</creatorcontrib><creatorcontrib>Simada, Hideki</creatorcontrib><creatorcontrib>Fukuma, Eisai</creatorcontrib><creatorcontrib>Ibii, Takahisa</creatorcontrib><creatorcontrib>Sato, Hideki</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iwata, Hiroo</au><au>Simada, Hideki</au><au>Fukuma, Eisai</au><au>Ibii, Takahisa</au><au>Sato, Hideki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioartificial Pancreas Research in Japan</atitle><jtitle>Artificial organs</jtitle><addtitle>Artif Organs</addtitle><date>2004-01</date><risdate>2004</risdate><volume>28</volume><issue>1</issue><spage>45</spage><epage>52</epage><pages>45-52</pages><issn>0160-564X</issn><eissn>1525-1594</eissn><abstract>: The bioartificial pancreas (BAP), a medical device enclosing insulin‐secreting cells in a semipermeable membrane, is expected to physiologically control glucose levels, and thus to be able to inhibit development of serious chronic complications in diabetic patients. In this brief review, we introduce research activities on the development of the BAP in Japan, including membrane preparation for the BAP, evaluation of in vitro and in vivo BAP functions, and challenges for production of insulin‐secreting cells from stem cells.</abstract><cop>Oxford, UK and Malden, USA</cop><pub>Blackwell Science Inc</pub><pmid>14720288</pmid><doi>10.1111/j.1525-1594.2004.07322.x</doi><tpages>8</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0160-564X
ispartof	Artificial organs, 2004-01, Vol.28 (1), p.45-52
issn	0160-564X 1525-1594
language	eng
recordid	cdi_proquest_miscellaneous_80091624
source	Wiley-Blackwell Read & Publish Collection
subjects	Animals Bioartificial pancreas Cell Differentiation Diabetes Diabetes Mellitus, Type 1 - therapy Embryo, Mammalian - cytology Equipment Design Humans Immunoisolation Insulin - metabolism Insulin Secretion Insulin-secreting cells Islet of Langerhans Islets of Langerhans Transplantation Japan Mice Pancreas Pancreas, Artificial Semipermeable membrane Stem Cells - cytology Tissue engineering Transplantation
title	Bioartificial Pancreas Research in Japan
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T23%3A48%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bioartificial%20Pancreas%20Research%20in%20Japan&rft.jtitle=Artificial%20organs&rft.au=Iwata,%20Hiroo&rft.date=2004-01&rft.volume=28&rft.issue=1&rft.spage=45&rft.epage=52&rft.pages=45-52&rft.issn=0160-564X&rft.eissn=1525-1594&rft_id=info:doi/10.1111/j.1525-1594.2004.07322.x&rft_dat=%3Cproquest_cross%3E80091624%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4782-ff03a441f0790795c5b2bfde48a76b7f3384edfc62cdc2f9bee53f3843afc7493%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=17754860&rft_id=info:pmid/14720288&rfr_iscdi=true