CEREBROSPINAL FLUID TRANSFER OF CEFBUPERAZONE IN THE BLOOD-BRAIN BARRIER LESIONS OF NEUROSURGICAL PATIENTS

Cefbuperazone (CBPZ) was given in 15 patients after surgery. There was no infections except for 1 case in which signs of infections were suspected. As side effects, slight elevations in hepatic transaminase levels were observed in 3 patients during the CBPZ chemotherapy. CBPZ concentrations in 7 pat...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1990/06/25, Vol.43(6), pp.1174-1180
Main Authors: NAKATA, MUNETOMO, MUKAWA, JIRO, MIYAGI, KOUICHI, KINJOU, TOSHIHIKO, SAKUTA, OSAMU, MIYAZATO, HIROSHI, OKUYAMA, KUNIO, HIGA, YASUSHI, TERADA, YUKITOSHI
Format: Article
Language:Japanese
Subjects:
Adolescent
Adult
Aged
Bacterial Infections - prevention & control
Blood-Brain Barrier
Brain Diseases - cerebrospinal fluid
Brain Diseases - surgery
Cephamycins - cerebrospinal fluid
Cephamycins - therapeutic use
Female
Humans
Infusions, Intravenous
Male
Middle Aged
Postoperative Complications - prevention & control
Premedication
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Summary:Cefbuperazone (CBPZ) was given in 15 patients after surgery. There was no infections except for 1 case in which signs of infections were suspected. As side effects, slight elevations in hepatic transaminase levels were observed in 3 patients during the CBPZ chemotherapy. CBPZ concentrations in 7 patients were studied. The subjects were divided into 3 groups according to CT findings during the chemotherapy to correlate CBPZ concentrations to degrees of blood-brain barrier lesions; Group I: no enhancement, Group II: mild or focal enhancement, Group III: diffuse and marked enhancement. It was interesting to note that the more marked enhancement were obtained, the higher levels of CSF concentration of CBPZ.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.43.1174