Vitamin D Receptor Genotype Is Associated With Fat-Free Mass and Sarcopenia in Elderly Men

We investigated the association of vitamin D receptor (VDR) genotype with fat-free mass (FFM) in a cohort of 302 older (aged 58–93 years) Caucasian men who underwent body composition analysis by dual-energy X-ray absorptiometry, and completed questionnaires addressing comorbidities, physical activit...

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Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2004-01, Vol.59 (1), p.B10-B15
Main Authors: Roth, Stephen M., Zmuda, Joseph M., Cauley, Jane A., Shea, Patrick R., Ferrell, Robert E.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Body Mass Index
Deoxyribonucleases, Type II Site-Specific - genetics
Disease
Genotype
Humans
Male
Medical procedures
Men
Middle Aged
Muscle, Skeletal - pathology
Older people
Polymorphism, Genetic
Receptors, Calcitriol - genetics
Site-Specific DNA-Methyltransferase (Adenine-Specific) - genetics
Vitamin D
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Summary:We investigated the association of vitamin D receptor (VDR) genotype with fat-free mass (FFM) in a cohort of 302 older (aged 58–93 years) Caucasian men who underwent body composition analysis by dual-energy X-ray absorptiometry, and completed questionnaires addressing comorbidities, physical activity, and dietary intake. All participants were genotyped for a VDR translation start site (FokI) polymorphism [FF (37.7%), Ff (48.4%), and ff (13.9%)] and the previously studied BsmI polymorphism [BB (24.9%), Bb (37.7%), and bb (37.4%)]. The BsmI polymorphism was not associated with FFM in any analysis; however, the FokI polymorphism was significantly associated with total FFM, appendicular FFM, and relative (kg/m2) appendicular FFM (all p
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/59.1.B10