Nucleic acid amplification tests for diagnosis of tuberculous meningitis

[...]studies were done to compare the sensitivity and the specificity of the NAA tests for detection ofMPB64 gene4 and IS61102 on different types (details not provided) of clinical specimens including cerebrospinal fluid (CSF) showing growth ofM tuberculosis. Theoretically, NAA tests are designed to...

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Bibliographic Details
Published in:The Lancet infectious diseases 2004-01, Vol.4 (1), p.9-9
Main Authors: Jayanthi, U, Madhavan, HN, Therese, K Lily
Format: Article
Language:English
Subjects:
Antigens, Bacterial - genetics
Bacterial Proteins - genetics
Deoxyribonucleic acid
DNA
DNA Primers
DNA Transposable Elements
DNA, Bacterial - analysis
Estimates
Humans
India
Infectious diseases
Medical diagnosis
Meningitis
Meta-analysis
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
Nucleic Acid Amplification Techniques
Nucleic acids
Sensitivity and Specificity
Tuberculosis
Tuberculosis, Meningeal - diagnosis
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Summary:[...]studies were done to compare the sensitivity and the specificity of the NAA tests for detection ofMPB64 gene4 and IS61102 on different types (details not provided) of clinical specimens including cerebrospinal fluid (CSF) showing growth ofM tuberculosis. Theoretically, NAA tests are designed to provide a positive signal from as little as a single copy of the target DNA or RNA. [...]one would expect a priori to see good to excellent NAA test sensitivity. [...]in the ligase chain reaction package insert, the “unresolved” sensitivity estimate of this NAA test for the diagnosis of smear-negative tuberculosis is 0·75 (0·61–0·86).
ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(03)00851-X