Usefulness of brain natriuretic peptide as a marker for separating cardiac and noncardiac causes of syncope

We retrospectively evaluated the feasibility of measuring brain natriuretic peptide to identify cardiac syncope in 148 consecutive patients with syncope. Sixty-one patients with cardiac syncope were identified. A cut-off value of 40 pg/ml was used to determine the cardiac causes of syncope; the sens...

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Bibliographic Details
Published in:The American journal of cardiology 2004-01, Vol.93 (2), p.228-230
Main Authors: Tanimoto, Kojiro, Yukiiri, Kazushi, Mizushige, Katsufumi, Takagi, Yuichiro, Masugata, Hisashi, Shinomiya, Kaori, Hosomi, Naohisa, Takahashi, Tsutomu, Ohmori, Koji, Kohno, Masakazu
Format: Article
Language:English
Subjects:
Aged
Algorithms
Arrhythmias, Cardiac - complications
Biological and medical sciences
Cardiology. Vascular system
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Echocardiography
Electrocardiography
Electrocardiography, Ambulatory
Feasibility Studies
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Heart
Heart Diseases - complications
Humans
Male
Medical sciences
Natriuretic Peptide, Brain - blood
Nervous system (semeiology, syndromes)
Neurology
Retrospective Studies
Sensitivity and Specificity
Syncope - diagnosis
Syncope - etiology
Syncope, Vasovagal - diagnosis
Tilt-Table Test
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Description
Summary:We retrospectively evaluated the feasibility of measuring brain natriuretic peptide to identify cardiac syncope in 148 consecutive patients with syncope. Sixty-one patients with cardiac syncope were identified. A cut-off value of 40 pg/ml was used to determine the cardiac causes of syncope; the sensitivity and specificity for identification of cardiac syncope were 82% and 92%, respectively. Thus, measurement of brain natriuretic peptide concentrations may help confirm cardiac causes of syncope, and merits consideration for incorporation into the algorithm used to diagnose syncope.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2003.09.048