Miniature endoscope for simultaneous optical coherence tomography and laser-induced fluorescence measurement

We have designed a multimodality system that combines optical coherence tomography (OCT) and laser-induced fluorescence (LIF) in a 2.0-mm-diameter endoscopic package. OCT provides approximately 18-microm resolution cross-sectional structural information over a 6-mm field. LIF spectra are collected s...

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Bibliographic Details
Published in:Applied optics (2004) 2004-01, Vol.43 (1), p.113-121
Main Authors: Tumlinson, Alexandre R, Hariri, Lida P, Utzinger, Urs, Barton, Jennifer K
Format: Article
Language:English
Subjects:
Animals
Colonoscopes
Colonoscopy
Coloring Agents
Endoscopes
Equipment Design
Fluorescence
Lasers
Mice
Tomography, Optical Coherence - instrumentation
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Description
Summary:We have designed a multimodality system that combines optical coherence tomography (OCT) and laser-induced fluorescence (LIF) in a 2.0-mm-diameter endoscopic package. OCT provides approximately 18-microm resolution cross-sectional structural information over a 6-mm field. LIF spectra are collected sequentially at submillimeter resolution across the same field and provide histochemical information about the tissue. We present the use of a rod prism to reduce the asymmetry in the OCT beam caused by a cylindrical window. The endoscope has been applied to investigate mouse colon cancer in vivo.
ISSN:1559-128X
DOI:10.1364/AO.43.000113