Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

Class I MHC molecules acquire peptides from endogenously synthesized proteins, whereas class II antigens present peptides derived from extracellular compartment molecules. This dichotomy is due to the fact that the invariant chain associates with class II molecules in the endoplasmic reticulum, prev...

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Bibliographic Details
Published in:Nature (London) 1990-11, Vol.348 (6296), p.39-44
Main Authors: TEYTON, L, O'SULLIVAN, D, DICKSON, P. W, LOTTEAU, V, SETTE, A, FINK, P, PETERSON, P. A
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Antigen presentation
Antigen-Presenting Cells - immunology
Antigens
Antigens, Differentiation, B-Lymphocyte
Autoimmune diseases
Base Sequence
Binding
Binding, Competitive
Biochemistry
Biological and medical sciences
Chains
Chemical synthesis
Chromatography
DNA - genetics
Endocytosis
Endoplasmic reticulum
Endoplasmic Reticulum - metabolism
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genetics
HeLa Cells
Histocompatibility antigens (hla, h-2 and other systems)
Histocompatibility Antigens Class II - chemistry
Histocompatibility Antigens Class II - genetics
Histocompatibility Antigens Class II - immunology
Histocompatibility Antigens Class II - metabolism
HLA-DQ Antigens - immunology
HLA-DQ Antigens - metabolism
HLA-DR Antigens - metabolism
Humans
Immunity (Disease)
Immunosorbent Techniques
Invariant chain
Invariants
Leukemia
Macromolecular Substances
Medical research
Membrane Proteins - immunology
Molecular immunology
Molecular Sequence Data
Peptides
Peptides - immunology
Peptides - metabolism
Protein Sorting Signals - immunology
Proteins
T-Lymphocytes - immunology
Transfection
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Description
Summary:Class I MHC molecules acquire peptides from endogenously synthesized proteins, whereas class II antigens present peptides derived from extracellular compartment molecules. This dichotomy is due to the fact that the invariant chain associates with class II molecules in the endoplasmic reticulum, preventing binding of endogenous peptides. The mutually exclusive binding of peptide and invariant chain to class II molecules suggests that the invariant chain might play a part in autoimmune disease.
ISSN:0028-0836
1476-4687
DOI:10.1038/348039a0