Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

Class I MHC molecules acquire peptides from endogenously synthesized proteins, whereas class II antigens present peptides derived from extracellular compartment molecules. This dichotomy is due to the fact that the invariant chain associates with class II molecules in the endoplasmic reticulum, prev...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1990-11, Vol.348 (6296), p.39-44
Main Authors: TEYTON, L, O'SULLIVAN, D, DICKSON, P. W, LOTTEAU, V, SETTE, A, FINK, P, PETERSON, P. A
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Antigen presentation
Antigen-Presenting Cells - immunology
Antigens
Antigens, Differentiation, B-Lymphocyte
Autoimmune diseases
Base Sequence
Binding
Binding, Competitive
Biochemistry
Biological and medical sciences
Chains
Chemical synthesis
Chromatography
DNA - genetics
Endocytosis
Endoplasmic reticulum
Endoplasmic Reticulum - metabolism
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genetics
HeLa Cells
Histocompatibility antigens (hla, h-2 and other systems)
Histocompatibility Antigens Class II - chemistry
Histocompatibility Antigens Class II - genetics
Histocompatibility Antigens Class II - immunology
Histocompatibility Antigens Class II - metabolism
HLA-DQ Antigens - immunology
HLA-DQ Antigens - metabolism
HLA-DR Antigens - metabolism
Humans
Immunity (Disease)
Immunosorbent Techniques
Invariant chain
Invariants
Leukemia
Macromolecular Substances
Medical research
Membrane Proteins - immunology
Molecular immunology
Molecular Sequence Data
Peptides
Peptides - immunology
Peptides - metabolism
Protein Sorting Signals - immunology
Proteins
T-Lymphocytes - immunology
Transfection
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c426t-6efea9763fa5123dfb07381e8f3b82abc10b49ae0f0ae942b14a685a641d47633
cites cdi_FETCH-LOGICAL-c426t-6efea9763fa5123dfb07381e8f3b82abc10b49ae0f0ae942b14a685a641d47633
container_end_page 44
container_issue 6296
container_start_page 39
container_title Nature (London)
container_volume 348
creator TEYTON, L
O'SULLIVAN, D
DICKSON, P. W
LOTTEAU, V
SETTE, A
FINK, P
PETERSON, P. A
description Class I MHC molecules acquire peptides from endogenously synthesized proteins, whereas class II antigens present peptides derived from extracellular compartment molecules. This dichotomy is due to the fact that the invariant chain associates with class II molecules in the endoplasmic reticulum, preventing binding of endogenous peptides. The mutually exclusive binding of peptide and invariant chain to class II molecules suggests that the invariant chain might play a part in autoimmune disease.
doi_str_mv 10.1038/348039a0
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80098768</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1728531</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-6efea9763fa5123dfb07381e8f3b82abc10b49ae0f0ae942b14a685a641d47633</originalsourceid><addsrcrecordid>eNqFkd9rFDEQx4Mo9VoF_wFhUaq-rE6S2WzyKMUfhYIv-rzO7s72Uu6yZ5K19r83R08LgvqUGebDh3xnhHgi4bUEbd9otKAdwT2xktiaGo1t74sVgLI1WG0eiuOUrgCgkS0eiSOlNELTrsTX8_CdoqeQq2FNPlSjT9mHy8WnNaeq53zNHKq85op_zJcc5iVVFMaKw3jXZl_Kahc5cciU_VwayutrukmPxIOJNokfH94T8eX9u89nH-uLTx_Oz95e1AMqk2vDE5NrjZ6okUqPUw-ttpLtpHurqB8k9OiIYQJih6qXSMY2ZFCOJbDWJ-LFrXcX528Lp9xtfRp4s6HA5ZOdBXC2NbaAL_8Jtqh1U5Zj_quUxqCTjSvg8z_Aq3mJocTtyqK1A4Vur3v2VwoQlTZ2r3p1Cw1xTiny1O2i31K86SR0-1N3v05d0KcH39JvefwNHm5b5qeHOaWBNlOkMPh053MasaTUPwFdhK-B</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>204423689</pqid></control><display><type>article</type><title>Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways</title><source>North East Research Libraries Nature Academic Titles</source><creator>TEYTON, L ; O'SULLIVAN, D ; DICKSON, P. W ; LOTTEAU, V ; SETTE, A ; FINK, P ; PETERSON, P. A</creator><creatorcontrib>TEYTON, L ; O'SULLIVAN, D ; DICKSON, P. W ; LOTTEAU, V ; SETTE, A ; FINK, P ; PETERSON, P. A</creatorcontrib><description>Class I MHC molecules acquire peptides from endogenously synthesized proteins, whereas class II antigens present peptides derived from extracellular compartment molecules. This dichotomy is due to the fact that the invariant chain associates with class II molecules in the endoplasmic reticulum, preventing binding of endogenous peptides. The mutually exclusive binding of peptide and invariant chain to class II molecules suggests that the invariant chain might play a part in autoimmune disease.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/348039a0</identifier><identifier>PMID: 2234057</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Amino Acid Sequence ; Animals ; Antigen presentation ; Antigen-Presenting Cells - immunology ; Antigens ; Antigens, Differentiation, B-Lymphocyte ; Autoimmune diseases ; Base Sequence ; Binding ; Binding, Competitive ; Biochemistry ; Biological and medical sciences ; Chains ; Chemical synthesis ; Chromatography ; DNA - genetics ; Endocytosis ; Endoplasmic reticulum ; Endoplasmic Reticulum - metabolism ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genetics ; HeLa Cells ; Histocompatibility antigens (hla, h-2 and other systems) ; Histocompatibility Antigens Class II - chemistry ; Histocompatibility Antigens Class II - genetics ; Histocompatibility Antigens Class II - immunology ; Histocompatibility Antigens Class II - metabolism ; HLA-DQ Antigens - immunology ; HLA-DQ Antigens - metabolism ; HLA-DR Antigens - metabolism ; Humans ; Immunity (Disease) ; Immunosorbent Techniques ; Invariant chain ; Invariants ; Leukemia ; Macromolecular Substances ; Medical research ; Membrane Proteins - immunology ; Molecular immunology ; Molecular Sequence Data ; Peptides ; Peptides - immunology ; Peptides - metabolism ; Protein Sorting Signals - immunology ; Proteins ; T-Lymphocytes - immunology ; Transfection</subject><ispartof>Nature (London), 1990-11, Vol.348 (6296), p.39-44</ispartof><rights>1991 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Nov 1, 1990</rights><rights>Copyright Nature Publishing Group Nov 1, 1990</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-6efea9763fa5123dfb07381e8f3b82abc10b49ae0f0ae942b14a685a641d47633</citedby><cites>FETCH-LOGICAL-c426t-6efea9763fa5123dfb07381e8f3b82abc10b49ae0f0ae942b14a685a641d47633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27898,27899</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=19344563$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2234057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TEYTON, L</creatorcontrib><creatorcontrib>O'SULLIVAN, D</creatorcontrib><creatorcontrib>DICKSON, P. W</creatorcontrib><creatorcontrib>LOTTEAU, V</creatorcontrib><creatorcontrib>SETTE, A</creatorcontrib><creatorcontrib>FINK, P</creatorcontrib><creatorcontrib>PETERSON, P. A</creatorcontrib><title>Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways</title><title>Nature (London)</title><addtitle>Nature</addtitle><description>Class I MHC molecules acquire peptides from endogenously synthesized proteins, whereas class II antigens present peptides derived from extracellular compartment molecules. This dichotomy is due to the fact that the invariant chain associates with class II molecules in the endoplasmic reticulum, preventing binding of endogenous peptides. The mutually exclusive binding of peptide and invariant chain to class II molecules suggests that the invariant chain might play a part in autoimmune disease.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antigen presentation</subject><subject>Antigen-Presenting Cells - immunology</subject><subject>Antigens</subject><subject>Antigens, Differentiation, B-Lymphocyte</subject><subject>Autoimmune diseases</subject><subject>Base Sequence</subject><subject>Binding</subject><subject>Binding, Competitive</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Chains</subject><subject>Chemical synthesis</subject><subject>Chromatography</subject><subject>DNA - genetics</subject><subject>Endocytosis</subject><subject>Endoplasmic reticulum</subject><subject>Endoplasmic Reticulum - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genetics</subject><subject>HeLa Cells</subject><subject>Histocompatibility antigens (hla, h-2 and other systems)</subject><subject>Histocompatibility Antigens Class II - chemistry</subject><subject>Histocompatibility Antigens Class II - genetics</subject><subject>Histocompatibility Antigens Class II - immunology</subject><subject>Histocompatibility Antigens Class II - metabolism</subject><subject>HLA-DQ Antigens - immunology</subject><subject>HLA-DQ Antigens - metabolism</subject><subject>HLA-DR Antigens - metabolism</subject><subject>Humans</subject><subject>Immunity (Disease)</subject><subject>Immunosorbent Techniques</subject><subject>Invariant chain</subject><subject>Invariants</subject><subject>Leukemia</subject><subject>Macromolecular Substances</subject><subject>Medical research</subject><subject>Membrane Proteins - immunology</subject><subject>Molecular immunology</subject><subject>Molecular Sequence Data</subject><subject>Peptides</subject><subject>Peptides - immunology</subject><subject>Peptides - metabolism</subject><subject>Protein Sorting Signals - immunology</subject><subject>Proteins</subject><subject>T-Lymphocytes - immunology</subject><subject>Transfection</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNqFkd9rFDEQx4Mo9VoF_wFhUaq-rE6S2WzyKMUfhYIv-rzO7s72Uu6yZ5K19r83R08LgvqUGebDh3xnhHgi4bUEbd9otKAdwT2xktiaGo1t74sVgLI1WG0eiuOUrgCgkS0eiSOlNELTrsTX8_CdoqeQq2FNPlSjT9mHy8WnNaeq53zNHKq85op_zJcc5iVVFMaKw3jXZl_Kahc5cciU_VwayutrukmPxIOJNokfH94T8eX9u89nH-uLTx_Oz95e1AMqk2vDE5NrjZ6okUqPUw-ttpLtpHurqB8k9OiIYQJih6qXSMY2ZFCOJbDWJ-LFrXcX528Lp9xtfRp4s6HA5ZOdBXC2NbaAL_8Jtqh1U5Zj_quUxqCTjSvg8z_Aq3mJocTtyqK1A4Vur3v2VwoQlTZ2r3p1Cw1xTiny1O2i31K86SR0-1N3v05d0KcH39JvefwNHm5b5qeHOaWBNlOkMPh053MasaTUPwFdhK-B</recordid><startdate>19901101</startdate><enddate>19901101</enddate><creator>TEYTON, L</creator><creator>O'SULLIVAN, D</creator><creator>DICKSON, P. W</creator><creator>LOTTEAU, V</creator><creator>SETTE, A</creator><creator>FINK, P</creator><creator>PETERSON, P. A</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7SC</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope></search><sort><creationdate>19901101</creationdate><title>Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways</title><author>TEYTON, L ; O'SULLIVAN, D ; DICKSON, P. W ; LOTTEAU, V ; SETTE, A ; FINK, P ; PETERSON, P. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-6efea9763fa5123dfb07381e8f3b82abc10b49ae0f0ae942b14a685a641d47633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antigen presentation</topic><topic>Antigen-Presenting Cells - immunology</topic><topic>Antigens</topic><topic>Antigens, Differentiation, B-Lymphocyte</topic><topic>Autoimmune diseases</topic><topic>Base Sequence</topic><topic>Binding</topic><topic>Binding, Competitive</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Chains</topic><topic>Chemical synthesis</topic><topic>Chromatography</topic><topic>DNA - genetics</topic><topic>Endocytosis</topic><topic>Endoplasmic reticulum</topic><topic>Endoplasmic Reticulum - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genetics</topic><topic>HeLa Cells</topic><topic>Histocompatibility antigens (hla, h-2 and other systems)</topic><topic>Histocompatibility Antigens Class II - chemistry</topic><topic>Histocompatibility Antigens Class II - genetics</topic><topic>Histocompatibility Antigens Class II - immunology</topic><topic>Histocompatibility Antigens Class II - metabolism</topic><topic>HLA-DQ Antigens - immunology</topic><topic>HLA-DQ Antigens - metabolism</topic><topic>HLA-DR Antigens - metabolism</topic><topic>Humans</topic><topic>Immunity (Disease)</topic><topic>Immunosorbent Techniques</topic><topic>Invariant chain</topic><topic>Invariants</topic><topic>Leukemia</topic><topic>Macromolecular Substances</topic><topic>Medical research</topic><topic>Membrane Proteins - immunology</topic><topic>Molecular immunology</topic><topic>Molecular Sequence Data</topic><topic>Peptides</topic><topic>Peptides - immunology</topic><topic>Peptides - metabolism</topic><topic>Protein Sorting Signals - immunology</topic><topic>Proteins</topic><topic>T-Lymphocytes - immunology</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TEYTON, L</creatorcontrib><creatorcontrib>O'SULLIVAN, D</creatorcontrib><creatorcontrib>DICKSON, P. W</creatorcontrib><creatorcontrib>LOTTEAU, V</creatorcontrib><creatorcontrib>SETTE, A</creatorcontrib><creatorcontrib>FINK, P</creatorcontrib><creatorcontrib>PETERSON, P. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Proquest Nursing &amp; Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric &amp; Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest Research Library</collection><collection>ProQuest Science Journals</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric &amp; Aquatic Science Database</collection><collection>Materials science collection</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health &amp; Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health &amp; Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied &amp; Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>Environment Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Electronics &amp; Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical &amp; Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology &amp; Engineering</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts – Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TEYTON, L</au><au>O'SULLIVAN, D</au><au>DICKSON, P. W</au><au>LOTTEAU, V</au><au>SETTE, A</au><au>FINK, P</au><au>PETERSON, P. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways</atitle><jtitle>Nature (London)</jtitle><addtitle>Nature</addtitle><date>1990-11-01</date><risdate>1990</risdate><volume>348</volume><issue>6296</issue><spage>39</spage><epage>44</epage><pages>39-44</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>Class I MHC molecules acquire peptides from endogenously synthesized proteins, whereas class II antigens present peptides derived from extracellular compartment molecules. This dichotomy is due to the fact that the invariant chain associates with class II molecules in the endoplasmic reticulum, preventing binding of endogenous peptides. The mutually exclusive binding of peptide and invariant chain to class II molecules suggests that the invariant chain might play a part in autoimmune disease.</abstract><cop>London</cop><pub>Nature Publishing</pub><pmid>2234057</pmid><doi>10.1038/348039a0</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0028-0836
ispartof Nature (London), 1990-11, Vol.348 (6296), p.39-44
issn 0028-0836
1476-4687
language eng
recordid cdi_proquest_miscellaneous_80098768
source North East Research Libraries Nature Academic Titles
subjects Amino Acid Sequence
Animals
Antigen presentation
Antigen-Presenting Cells - immunology
Antigens
Antigens, Differentiation, B-Lymphocyte
Autoimmune diseases
Base Sequence
Binding
Binding, Competitive
Biochemistry
Biological and medical sciences
Chains
Chemical synthesis
Chromatography
DNA - genetics
Endocytosis
Endoplasmic reticulum
Endoplasmic Reticulum - metabolism
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genetics
HeLa Cells
Histocompatibility antigens (hla, h-2 and other systems)
Histocompatibility Antigens Class II - chemistry
Histocompatibility Antigens Class II - genetics
Histocompatibility Antigens Class II - immunology
Histocompatibility Antigens Class II - metabolism
HLA-DQ Antigens - immunology
HLA-DQ Antigens - metabolism
HLA-DR Antigens - metabolism
Humans
Immunity (Disease)
Immunosorbent Techniques
Invariant chain
Invariants
Leukemia
Macromolecular Substances
Medical research
Membrane Proteins - immunology
Molecular immunology
Molecular Sequence Data
Peptides
Peptides - immunology
Peptides - metabolism
Protein Sorting Signals - immunology
Proteins
T-Lymphocytes - immunology
Transfection
title Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-03-04T16%3A28%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Invariant%20chain%20distinguishes%20between%20the%20exogenous%20and%20endogenous%20antigen%20presentation%20pathways&rft.jtitle=Nature%20(London)&rft.au=TEYTON,%20L&rft.date=1990-11-01&rft.volume=348&rft.issue=6296&rft.spage=39&rft.epage=44&rft.pages=39-44&rft.issn=0028-0836&rft.eissn=1476-4687&rft.coden=NATUAS&rft_id=info:doi/10.1038/348039a0&rft_dat=%3Cproquest_cross%3E1728531%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c426t-6efea9763fa5123dfb07381e8f3b82abc10b49ae0f0ae942b14a685a641d47633%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=204423689&rft_id=info:pmid/2234057&rfr_iscdi=true