Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis

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Bibliographic Details
Published in:Journal of medicinal chemistry 1990-11, Vol.33 (11), p.2952-2956
Main Authors: Karanewsky, D S, Badia, M C, Ciosek, Jr, C P, Robl, J A, Sofia, M J, Simpkins, L M, DeLange, B, Harrity, T W, Biller, S A, Gordon, E M
Format: Article
Language:English
Subjects:
Animals
Anticholesteremic Agents - chemical synthesis
Anticholesteremic Agents - chemistry
Anticholesteremic Agents - pharmacology
Butyrates - chemical synthesis
Butyrates - chemistry
Butyrates - pharmacology
Cholesterol - biosynthesis
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Indoles - chemical synthesis
Indoles - chemistry
Indoles - pharmacology
Liver - enzymology
Molecular Structure
Organophosphorus Compounds - chemical synthesis
Organophosphorus Compounds - chemistry
Organophosphorus Compounds - pharmacology
Rats
Structure-Activity Relationship
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ISSN:0022-2623
DOI:10.1021/jm00173a007