Loading…
Binuclear copper(II) complexes of tolfenamic: synthesis, crystal structure, spectroscopy and superoxide dismutase activity
The synthesis and characterization of copper(II) complexes with a potent non-steroidal anti-inflammatory drug, tolfenamic acid, Htolf, with formula [Cu(tolf) 2L] 2 (where L is H 2O or DMF, N, N-dimethylformamide) were investigated. The crystal and molecular structure of [Cu(tolf) 2(DMF)] 2 was repor...
Saved in:
| Published in: | Journal of inorganic biochemistry 2004-02, Vol.98 (2), p.358-364 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c367t-ab1bff7c927a5af7a576dd25b096e1ae216dddc7561d78ccad15fef4c438bac3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c367t-ab1bff7c927a5af7a576dd25b096e1ae216dddc7561d78ccad15fef4c438bac3 |
| container_end_page | 364 |
| container_issue | 2 |
| container_start_page | 358 |
| container_title | Journal of inorganic biochemistry |
| container_volume | 98 |
| creator | Kovala-Demertzi, Dimitra Galani, Angeliki Demertzis, Mavroudis A Skoulika, Stavroula Kotoglou, Chronis |
| description | The synthesis and characterization of copper(II) complexes with a potent non-steroidal anti-inflammatory drug, tolfenamic acid, Htolf, with formula [Cu(tolf)
2L]
2 (where L is H
2O or DMF,
N,
N-dimethylformamide) were investigated. The crystal and molecular structure of [Cu(tolf)
2(DMF)]
2 was reported. Crystallographic data are as follows: monoclinic system, space group
P2
1/
n with cell constants
a=9.068(2) Å,
b=14.514(3) Å,
c=22.826(4) Å,
V=2948.9(10) Å
3 and
Z=2. The crystal structure consists of binuclear, quadruply bridged neutral molecule with a Cu–Cu bond length of 2.6075(19) Å. The complex is self-assembled via C–H–π intermolecular stacking interactions. Spectroscopic and electrochemical studies were reported. The superoxide dismutase activity is measured and compared with those of superoxide dismutase enzyme, SOD, the free ligand and related copper complexes with non-steroidal anti-inflammatory drugs, NSAIDs. IC
50 value was measured by the Fridovich test (1.97±0.17 μM), which showed that [Cu(tolf)
2L]
2 is a good superoxide scavenger. |
| doi_str_mv | 10.1016/j.jinorgbio.2003.11.004 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80100752</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0162013403004410</els_id><sourcerecordid>80100752</sourcerecordid><originalsourceid>FETCH-LOGICAL-c367t-ab1bff7c927a5af7a576dd25b096e1ae216dddc7561d78ccad15fef4c438bac3</originalsourceid><addsrcrecordid>eNqFkE1v1DAQhi1ERZfCXwCfEEhNasdJvMutVHysVKmX3i1nPAGvkjh4nKrh19fVruDIZTyWnnlH8zD2XopSCtleHcqDn0L82flQVkKoUspSiPoF28itVoVSdf2SbTJZFUKq-py9JjoIIZqm1q_Yuax1tVOy3bA_X_y0wIA2cgjzjPHjfv8pt-M84CMSDz1PYehxsqOHz5zWKf1C8nTJIa6U7MApxQXSEvGS04yQYqCctHI7OU5LTgyP3iF3nsYlWUJuIfkHn9Y37Ky3A-Hb03vB7r99vb_5Udzefd_fXN8WoFqdCtvJru817CptG9vnolvnqqYTuxalxUrmrwPdtNLpLYB1sumxr6FW286CumAfjrFzDL8XpGRGT4DDYCcMC5mtkELopsqgPoKQT6CIvZmjH21cjRTm2bo5mL_WzbN1I6XJ1vPku9OKpRvR_Zs7ac7A9RHAfOeDx2gIPE6AzseszLjg_7vkCau-nIM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80100752</pqid></control><display><type>article</type><title>Binuclear copper(II) complexes of tolfenamic: synthesis, crystal structure, spectroscopy and superoxide dismutase activity</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Kovala-Demertzi, Dimitra ; Galani, Angeliki ; Demertzis, Mavroudis A ; Skoulika, Stavroula ; Kotoglou, Chronis</creator><creatorcontrib>Kovala-Demertzi, Dimitra ; Galani, Angeliki ; Demertzis, Mavroudis A ; Skoulika, Stavroula ; Kotoglou, Chronis</creatorcontrib><description>The synthesis and characterization of copper(II) complexes with a potent non-steroidal anti-inflammatory drug, tolfenamic acid, Htolf, with formula [Cu(tolf)
2L]
2 (where L is H
2O or DMF,
N,
N-dimethylformamide) were investigated. The crystal and molecular structure of [Cu(tolf)
2(DMF)]
2 was reported. Crystallographic data are as follows: monoclinic system, space group
P2
1/
n with cell constants
a=9.068(2) Å,
b=14.514(3) Å,
c=22.826(4) Å,
V=2948.9(10) Å
3 and
Z=2. The crystal structure consists of binuclear, quadruply bridged neutral molecule with a Cu–Cu bond length of 2.6075(19) Å. The complex is self-assembled via C–H–π intermolecular stacking interactions. Spectroscopic and electrochemical studies were reported. The superoxide dismutase activity is measured and compared with those of superoxide dismutase enzyme, SOD, the free ligand and related copper complexes with non-steroidal anti-inflammatory drugs, NSAIDs. IC
50 value was measured by the Fridovich test (1.97±0.17 μM), which showed that [Cu(tolf)
2L]
2 is a good superoxide scavenger.</description><identifier>ISSN: 0162-0134</identifier><identifier>EISSN: 1873-3344</identifier><identifier>DOI: 10.1016/j.jinorgbio.2003.11.004</identifier><identifier>PMID: 14729316</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Crystal structure ; NSAIDs ; SOD mimetic ; Spectroscopic study ; Tolfenamic</subject><ispartof>Journal of inorganic biochemistry, 2004-02, Vol.98 (2), p.358-364</ispartof><rights>2003 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-ab1bff7c927a5af7a576dd25b096e1ae216dddc7561d78ccad15fef4c438bac3</citedby><cites>FETCH-LOGICAL-c367t-ab1bff7c927a5af7a576dd25b096e1ae216dddc7561d78ccad15fef4c438bac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14729316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kovala-Demertzi, Dimitra</creatorcontrib><creatorcontrib>Galani, Angeliki</creatorcontrib><creatorcontrib>Demertzis, Mavroudis A</creatorcontrib><creatorcontrib>Skoulika, Stavroula</creatorcontrib><creatorcontrib>Kotoglou, Chronis</creatorcontrib><title>Binuclear copper(II) complexes of tolfenamic: synthesis, crystal structure, spectroscopy and superoxide dismutase activity</title><title>Journal of inorganic biochemistry</title><addtitle>J Inorg Biochem</addtitle><description>The synthesis and characterization of copper(II) complexes with a potent non-steroidal anti-inflammatory drug, tolfenamic acid, Htolf, with formula [Cu(tolf)
2L]
2 (where L is H
2O or DMF,
N,
N-dimethylformamide) were investigated. The crystal and molecular structure of [Cu(tolf)
2(DMF)]
2 was reported. Crystallographic data are as follows: monoclinic system, space group
P2
1/
n with cell constants
a=9.068(2) Å,
b=14.514(3) Å,
c=22.826(4) Å,
V=2948.9(10) Å
3 and
Z=2. The crystal structure consists of binuclear, quadruply bridged neutral molecule with a Cu–Cu bond length of 2.6075(19) Å. The complex is self-assembled via C–H–π intermolecular stacking interactions. Spectroscopic and electrochemical studies were reported. The superoxide dismutase activity is measured and compared with those of superoxide dismutase enzyme, SOD, the free ligand and related copper complexes with non-steroidal anti-inflammatory drugs, NSAIDs. IC
50 value was measured by the Fridovich test (1.97±0.17 μM), which showed that [Cu(tolf)
2L]
2 is a good superoxide scavenger.</description><subject>Crystal structure</subject><subject>NSAIDs</subject><subject>SOD mimetic</subject><subject>Spectroscopic study</subject><subject>Tolfenamic</subject><issn>0162-0134</issn><issn>1873-3344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqFkE1v1DAQhi1ERZfCXwCfEEhNasdJvMutVHysVKmX3i1nPAGvkjh4nKrh19fVruDIZTyWnnlH8zD2XopSCtleHcqDn0L82flQVkKoUspSiPoF28itVoVSdf2SbTJZFUKq-py9JjoIIZqm1q_Yuax1tVOy3bA_X_y0wIA2cgjzjPHjfv8pt-M84CMSDz1PYehxsqOHz5zWKf1C8nTJIa6U7MApxQXSEvGS04yQYqCctHI7OU5LTgyP3iF3nsYlWUJuIfkHn9Y37Ky3A-Hb03vB7r99vb_5Udzefd_fXN8WoFqdCtvJru817CptG9vnolvnqqYTuxalxUrmrwPdtNLpLYB1sumxr6FW286CumAfjrFzDL8XpGRGT4DDYCcMC5mtkELopsqgPoKQT6CIvZmjH21cjRTm2bo5mL_WzbN1I6XJ1vPku9OKpRvR_Zs7ac7A9RHAfOeDx2gIPE6AzseszLjg_7vkCau-nIM</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Kovala-Demertzi, Dimitra</creator><creator>Galani, Angeliki</creator><creator>Demertzis, Mavroudis A</creator><creator>Skoulika, Stavroula</creator><creator>Kotoglou, Chronis</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>Binuclear copper(II) complexes of tolfenamic: synthesis, crystal structure, spectroscopy and superoxide dismutase activity</title><author>Kovala-Demertzi, Dimitra ; Galani, Angeliki ; Demertzis, Mavroudis A ; Skoulika, Stavroula ; Kotoglou, Chronis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-ab1bff7c927a5af7a576dd25b096e1ae216dddc7561d78ccad15fef4c438bac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Crystal structure</topic><topic>NSAIDs</topic><topic>SOD mimetic</topic><topic>Spectroscopic study</topic><topic>Tolfenamic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kovala-Demertzi, Dimitra</creatorcontrib><creatorcontrib>Galani, Angeliki</creatorcontrib><creatorcontrib>Demertzis, Mavroudis A</creatorcontrib><creatorcontrib>Skoulika, Stavroula</creatorcontrib><creatorcontrib>Kotoglou, Chronis</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of inorganic biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kovala-Demertzi, Dimitra</au><au>Galani, Angeliki</au><au>Demertzis, Mavroudis A</au><au>Skoulika, Stavroula</au><au>Kotoglou, Chronis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Binuclear copper(II) complexes of tolfenamic: synthesis, crystal structure, spectroscopy and superoxide dismutase activity</atitle><jtitle>Journal of inorganic biochemistry</jtitle><addtitle>J Inorg Biochem</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>98</volume><issue>2</issue><spage>358</spage><epage>364</epage><pages>358-364</pages><issn>0162-0134</issn><eissn>1873-3344</eissn><abstract>The synthesis and characterization of copper(II) complexes with a potent non-steroidal anti-inflammatory drug, tolfenamic acid, Htolf, with formula [Cu(tolf)
2L]
2 (where L is H
2O or DMF,
N,
N-dimethylformamide) were investigated. The crystal and molecular structure of [Cu(tolf)
2(DMF)]
2 was reported. Crystallographic data are as follows: monoclinic system, space group
P2
1/
n with cell constants
a=9.068(2) Å,
b=14.514(3) Å,
c=22.826(4) Å,
V=2948.9(10) Å
3 and
Z=2. The crystal structure consists of binuclear, quadruply bridged neutral molecule with a Cu–Cu bond length of 2.6075(19) Å. The complex is self-assembled via C–H–π intermolecular stacking interactions. Spectroscopic and electrochemical studies were reported. The superoxide dismutase activity is measured and compared with those of superoxide dismutase enzyme, SOD, the free ligand and related copper complexes with non-steroidal anti-inflammatory drugs, NSAIDs. IC
50 value was measured by the Fridovich test (1.97±0.17 μM), which showed that [Cu(tolf)
2L]
2 is a good superoxide scavenger.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>14729316</pmid><doi>10.1016/j.jinorgbio.2003.11.004</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0162-0134 |
| ispartof | Journal of inorganic biochemistry, 2004-02, Vol.98 (2), p.358-364 |
| issn | 0162-0134 1873-3344 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80100752 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Crystal structure NSAIDs SOD mimetic Spectroscopic study Tolfenamic |
| title | Binuclear copper(II) complexes of tolfenamic: synthesis, crystal structure, spectroscopy and superoxide dismutase activity |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T03%3A24%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Binuclear%20copper(II)%20complexes%20of%20tolfenamic:%20synthesis,%20crystal%20structure,%20spectroscopy%20and%20superoxide%20dismutase%20activity&rft.jtitle=Journal%20of%20inorganic%20biochemistry&rft.au=Kovala-Demertzi,%20Dimitra&rft.date=2004-02-01&rft.volume=98&rft.issue=2&rft.spage=358&rft.epage=364&rft.pages=358-364&rft.issn=0162-0134&rft.eissn=1873-3344&rft_id=info:doi/10.1016/j.jinorgbio.2003.11.004&rft_dat=%3Cproquest_cross%3E80100752%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c367t-ab1bff7c927a5af7a576dd25b096e1ae216dddc7561d78ccad15fef4c438bac3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=80100752&rft_id=info:pmid/14729316&rfr_iscdi=true |