Increase in soluble E-selectin level after PTCA and stent implantation: a potential marker of restenosis

Background: E-Selectin is expressed only on activated endothelial cells, and may be used as a marker of endothelial activation. The relationship between soluble form of E-selectin (sE-selectin) and development of restenosis after balloon angioplasty (PTCA) is controversial, and there are no data for...

Full description

Saved in:
Bibliographic Details
Published in:International journal of cardiology 2004, Vol.93 (1), p.13-18
Main Authors: Kilickap, Mustafa, Tutar, Eralp, Aydintug, Olcay, Pamir, Gulgun, Erol, Cetin, Tutkak, Huseyin, Oral, Dervis
Format: Article
Language:English
Subjects:
Analysis of Variance
Angina Pectoris - therapy
Angioplasty, Balloon, Coronary
Balloon angioplasty
Biological and medical sciences
Cardiology. Vascular system
Chi-Square Distribution
Coronary Angiography
Coronary Restenosis - diagnosis
Diseases of the cardiovascular system
E-Selectin
E-Selectin - blood
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Medical sciences
Middle Aged
Predictive Value of Tests
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Restenosis
Stent
Stents
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: E-Selectin is expressed only on activated endothelial cells, and may be used as a marker of endothelial activation. The relationship between soluble form of E-selectin (sE-selectin) and development of restenosis after balloon angioplasty (PTCA) is controversial, and there are no data for after stent implantation. We evaluated the role of serially measured sE-selectin levels in predicting the development of restenosis after PTCA and stent implantation. Methods: In sixty-one patients with stable angina pectoris who underwent PTCA ( n=20) or stent implantation ( n=41), peripheral blood samples were taken just before (baseline), at 3 and at 24 h after the intervention. sE-Selectin levels were measured by ELISA. Coronary angiography was repeated at 4–6 months after the intervention, and ≥50% stenosis at the site of the intervention was regarded as restenosis. Levels and time course of sE-selectin after the intervention were compared in patients with and those without restenosis. Results: sE-Selectin levels of the patients with and those without restenosis were similar at each of the three measurements, and significantly increased after the intervention both in the PTCA and stent groups ( P
ISSN:0167-5273
1874-1754
DOI:10.1016/S0167-5273(03)00111-6