Reactions on a Solid Surface. A Simple, Economical, and Efficient Acylation of Alcohols and Amines over Al2O3

Al2O3 brings about a rapid acylation of a range of alcohols and amines with acid chlorides and acid anhydrides, respectively. Amines are easily Boc- and Cbz-protected on reaction with Boc-anhydride and Cbz-Cl, respectively. The acylation of phenols is slow enough to allow chemoselective acylation of...

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Bibliographic Details
Published in:Journal of organic chemistry 2004-01, Vol.69 (2), p.577-580
Main Authors: Yadav, Veejendra K, Ganesh Babu, K
Format: Article
Language:English
Subjects:
Aliphatic compounds
Chemistry
Exact sciences and technology
Organic chemistry
Preparations and properties
Online Access:Get full text
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Summary:Al2O3 brings about a rapid acylation of a range of alcohols and amines with acid chlorides and acid anhydrides, respectively. Amines are easily Boc- and Cbz-protected on reaction with Boc-anhydride and Cbz-Cl, respectively. The acylation of phenols is slow enough to allow chemoselective acylation of alcohols and amines in the presence of phenols.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo035412f