Relationship between malondialdehyde level and glutathione peroxidase activity in diabetic rats

Background: This investigation describes the relationship between glutathione peroxidase activities, an antioxidant enzyme, and the oxidative status in diabetic rat blood. Methods: Malondialdehyde level and glutathione peroxidase activity were measured by spectrophotometric techniques. Results and c...

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Bibliographic Details
Published in:Clinica chimica acta 2004-02, Vol.340 (1), p.79-83
Main Authors: Qujeq, Durdi, Aliakbarpour, Hamid Reza, Kalavi, Khodaberdi
Format: Article
Language:English
Subjects:
Animals
Antioxidant enzyme
Antioxidants - metabolism
Blood Glucose - analysis
Body Weight
Diabetes Mellitus, Experimental - enzymology
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - pathology
Diabetic
Glucose
Glutathione Peroxidase - metabolism
Glutathione peroxidase activity
Male
Malondialdehyde
Malondialdehyde - metabolism
Oxidative damage
Oxidative Stress - physiology
Oxygen free radicals
Rat
Rats
Rats, Wistar
Spectrophotometry - methods
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Summary:Background: This investigation describes the relationship between glutathione peroxidase activities, an antioxidant enzyme, and the oxidative status in diabetic rat blood. Methods: Malondialdehyde level and glutathione peroxidase activity were measured by spectrophotometric techniques. Results and conclusions: Malondialdehyde content in the diabetic rats group was increased compared to that in the controls [3.08±0.32 (mean±S.E.) vs. 1.15±0.29 mmol/g hemoglobin, P>0.01]. Glutathione peroxidase activity in the diabetic rats group was increased compared to that in the control [10.27±1.39 (mean±S.E.) vs. 3.14±0.38 μmol NADPH/min/g hemoglobin, P>0.01]. Our results show a positive correlation between serum glutathione peroxidase and malondialdehyde concentration in diabetic rats.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cccn.2003.09.023